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Table 3 Meta-analysis of the association between the TGF-β1 + 869 T/C gene polymorphism with the risk of acute rejection in renal transplantation

From: Relationship between TGF-β1 + 869 T/C and + 915 G/C gene polymorphism and risk of acute rejection in renal transplantation recipients

Genetic contrasts

Groups and subgroups

Studies

Q test

Model selected

OR (95% CI)

P

P value

T vs C

Overall

15

0.30

Fixed

1.01 (0.88, 1.15)

0.93

 

Caucasian

9

0.78

Fixed

0.99 (0.84, 1.16)

0.88

Asian

4

0.02

Random

1.03 (0.58, 1.82)

0.93

African

1

Fixed

0.84 (0.52, 1.36)

0.47

TT vs (TC + CC)

Overall

17

0.19

Fixed

1.08 (0.89, 1.31)

0.44

 

Caucasian

10

0.45

Fixed

1.05 (0.83, 1.33)

0.67

Asian

5

0.03

Random

1.06 (0.47, 2.41)

0.88

African

1

Fixed

0.96 (0.54, 1.73)

0.90

CC vs (TC + TT)

Overall

16

0.57

Fixed

1.04 (0.84, 1.30)

0.70

 

Caucasian

9

0.89

Fixed

0.99 (0.76, 1.29)

0.95

Asian

4

0.13

Fixed

1.01 (0.62, 1.67)

0.96

African

1

Fixed

1.99 (0.72, 5.51)

0.19