Relationship between TGF-β1 + 869 T/C and + 915 G/C gene polymorphism and risk of acute rejection in renal transplantation recipients

Table 2 Characteristics of the studies evaluating the effects of the transforming growth factor-beta 1 (TGF-β1) +915 G/C gene polymorphism on the risk of acute rejection in renal transplantation patients

First author and	Country/District	Ethnicity		AR				Non-AR			HWE	NOS
year			TT	TC	CC	Total	TT	TC	CC	Total	(Y/N)	scores
Alakulppi et al. 2004	Finland	Caucasian	48	–	–	50	210	–	–	241	–	6
Park et al. 2004	Korea	Asian	13	0	0	13	151	0	0	151	Y	7
Dmitrienko et al. 2005	Canada	Caucasian	40	8	2	50	43	6	1	50	N	7
Li et al. 2007	China	Asian	40	6	4	50	49	15	6	70	Y	8
Seyhun et al. 2012	Turkey	Caucasian	17	1	1	19	48	23	0	71	Y	7
Dhaouadi et al. 2013	Tunisia	African	55	17	8	80	105	38	8	151	Y	7
Chen et al. 2014	France etc.	Caucasian	41	9	0	50	243	31	1	275	Y	7
Seyhun et al. 2015	Turkey	Caucasian	120	28	2	150	66	23	1	90	Y	7

AR acute rejection, Non-AR non- acute rejection, HWE Hardy-Weinberg equilibrium, Y yes, N no, NOS Newcastle–Ottawa scale. A total score of NOS for each study can vary from 0 (worst) to 9 (best), low-quality studies: 0 to 4 points; high-quality studies: 5 to 9 points