Relationship between TGF-β1 + 869 T/C and + 915 G/C gene polymorphism and risk of acute rejection in renal transplantation recipients

Table 1 Characteristics of studies evaluating the effects of the transforming growth factor-beta 1 (TGF-β1) + 869 T/C gene polymorphism on the risk of acute rejection in renal transplantation patients

First author and	Country/District	Ethnicity		AR				Non-AR			HWE	NOS
year			TT	TC	CC	Total	TT	TC	CC	Total	(Y/N)	scores
Marshall et al. 2000	UK	Caucasian	46	55	13	114	39	48	8	95	Y	8
Alakulppi et al. 2004	Finland	Caucasian	31	–	–	50	115	–	–	241	–	6
Ligeiro et al. 2004	Portugal	Caucasian	12	12	7	31	14	15	6	35	Y	7
Chow et al. 2005	China	Asian	8	–	–	52	13	–	–	77	–	8
Guo et al. 2005	China	Asian	18	15	6	39	18	57	15	90	N	6
Dmitrienko et al. 2005	Canada	Caucasian	16	24	10	50	16	24	10	50	Y	7
Gendzekhadze et al. 2006	Venezuela	Mixed	12	12	6	30	10	14	9	33	Y	8
Hueso et al. 2006	Spain	Caucasian	6	5	3	14	20	28	15	63	Y	6
Canossi et al. 2007	Italy	Caucasian	4	15	6	25	14	29	18	61	Y	7
Brabcova et al. 2007	Czech Republic	Caucasian	32	91	67	190	34	128	84	246	Y	7
Manchanda et al. 2008	India	Asian	1	11	6	18	19	45	18	82	Y	6
Mendoza-Carrera et al. 2008	México	Mixed	–	–	8	19	–	–	7	32	–	7
Grinyóet al 2008	Spain	Caucasian	18	34	11	63	66	69	26	161	Y	6
Karimi et al. 2012	Iran	Asian	5	8	16	29	17	24	30	71	N	7
Seyhun et al. 2012	Turkey	Caucasian	6	10	3	19	16	31	24	71	Y	7
Dhaouadi et al. 2013	Tunisia	African	55	17	8	80	105	38	8	151	Y	7
Saigo et al. 2014	Japan	Asian	5	16	3	24	22	61	38	121	Y	7
Seyhun et al. 2015	Turkey	Caucasian	6	15	7	28	16	28	18	62	Y	7

AR acute rejection, Non-AR non- acute rejection, HWE Hardy-Weinberg equilibrium, Y yes, N no, NOS Newcastle–Ottawa scale. A total score of NOS for each study can vary from 0 (worst) to 9 (best), low-quality studies: 0 to 4 points; high-quality studies: 5 to 9 points

ISSN: 1471-2350