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Table 2 Differentially expressed gene or gene product suggested by the closed BITOLA system

From: Using literature-based discovery to identify candidate genes for the interaction between myocardial infarction and depression

Gene or gene product

FreqXY

FreqYZ

FreqXY*FreqYZ

LPA

1

1

1

FCGR3B

2

7

14

STAR

4

1

4

ESR1

3

2

6

GNB3

4

1

4

PAG1

1

1

1

NSF

1

1

1

ESD

1

1

1

LCAT

1

1

1

DMD

3

1

3

AR

2

1

2

CNR1

1

2

2

CPAMD8

2

4

8

HLA-B

1

1

1

MTHFR

40

4

160

CD4

11

16

176

IL6

99

20

1980

RERE

1

1

1

PADI4

1

1

1

SERPINA1

1

1

1

PTPRC

8

1

8

PPBP

4

1

4

NCAM1

1

7

7

  1. Freq Frequency of co-occurrence of two concepts in literature, X starting concept “Myocardial infarction” Z: end concept “Major Depressive Disorder” or “Depressive disorder”