Effect of prematurity on genome wide methylation in the placenta

Schuster, Jessica; Uzun, Alper; Stablia, Joan; Schorl, Christoph; Mori, Mari; Padbury, James F.

doi:10.1186/s12881-019-0835-6

BMC Medical Genetics

Table 3 Annotated DMR’s Associated with Gestational Age

From: Effect of prematurity on genome wide methylation in the placenta

DMR Location	DMR Width	baseMean	log2FoldChange	padj	Annotation	Nearest Gene
chr11:1069274–1,070,940	1666	275.32	−0.077895692	0.000669	Distal Intergenic	MUC2
chr7:158509261–158,511,170	1909	785.4202	−0.055129353	0.001379	Distal Intergenic	NCAPG2
chr8:143302532–143,305,491	2959	708.6988	−0.057666861	0.001379	Intron	LINC00051
chr11:51578780–51,581,392	2612	5862.829	0.12089555	0.007632	Distal Intergenic	OR4C46
chr15:22741828–22,744,210	2382	1025.047	−0.091557436	0.007632	Exon	GOLGA6L1
chr17:21901995–21,907,966	5971	1435.135	0.114589697	0.008451	Promoter (<=1 kb)	FLJ36000
chr11:51587551–51,593,541	5990	6613.759	0.114797282	0.012877	Distal Intergenic	OR4C46
chr10:115540476–115,542,108	1632	369.5293	−0.058238042	0.015459	Promoter (2-3 kb)	MIR4483
chr4:9875–10,674	799	300.733	−0.066430834	0.020835	Distal Intergenic	ZNF595
chr5:49415136–49,417,649	2513	629.6273	0.098693759	0.020835	Distal Intergenic	EMB
chr15:56071747–56,073,363	1616	280.2815	−0.044766281	0.028409	Distal Intergenic	PRTG
chrY:59027085–59,033,404	6319	757.9891	0.085296918	0.028937	Distal Intergenic	SPRY3
chr10:127579482–127,584,720	5238	732.2817	0.072848407	0.032657	Promoter (<=1 kb)	DHX32
chr10:134878560–134,880,844	2284	289.1369	−0.080610086	0.032657	Distal Intergenic	ADGRA1
chr11:1795935–1,798,177	2242	452.7534	−0.059025405	0.032657	Distal Intergenic	MOB2
chr11:51570928–51,573,041	2113	623.7097	0.10472301	0.032657	Distal Intergenic	OR4C46
chr11:51581774–51,585,209	3435	3634.642	0.099090126	0.032657	Distal Intergenic	OR4C46
chr19:24622360–24,624,613	2253	338.0393	0.100239042	0.032657	Distal Intergenic	HAVCR1P1
chr2:60693762–60,695,701	1939	293.8868	−0.074300347	0.032657	Intron	BCL11A
chr2:90374619–90,378,951	4332	2470.989	0.08904097	0.032657	Intron	MIR4436A
chr2:92280419–92,282,186	1767	1109.498	0.085845619	0.032657	Distal Intergenic	ACTR3BP2
chr21:11121793–11,128,301	6508	1510.744	0.043743747	0.032657	Distal Intergenic	BAGE
chr5:49413369–49,415,026	1657	555.3467	0.102896519	0.032657	Distal Intergenic	EMB
chr6:58775746–58,780,286	4540	59,219.18	0.088992793	0.032657	Distal Intergenic	GUSBP4
chr6:132921367–132,922,856	1489	702.8588	−0.077101273	0.032657	Distal Intergenic	TAAR3
chr7:155125413–155,128,850	3437	1162.764	−0.038748136	0.032657	Distal Intergenic	INSIG1
chr7:155199140–155,201,882	2742	355.5753	−0.077494132	0.032657	Distal Intergenic	EN2
chr2:91603906–91,606,341	2435	1002.445	0.094259612	0.033077	Distal Intergenic	LOC654342
chr1:16888159–16,896,002	7843	1691.305	0.055571393	0.035079	3′ UTR	MIR3675
chr2:91595932–91,600,986	5054	2660.109	0.085847679	0.035079	Distal Intergenic	LOC654342
chr5:49428377–49,432,607	4230	1837.6	0.094529868	0.035079	Distal Intergenic	EMB
chr5:49434812–49,441,568	6756	3582.595	0.092033374	0.035079	Distal Intergenic	EMB
chr8:143093456–143,095,020	1564	434.2594	−0.048625159	0.037056	Distal Intergenic	MIR4472–1
chr9:43157894–43,160,792	2898	440.6311	−0.051599615	0.038038	Distal Intergenic	LOC642929
chr3:196625149–196,626,329	1180	5459.852	0.091127805	0.03925	Intron	SENP5
chr1:2775172–2,776,643	1471	300.3145	−0.049869539	0.043507	Distal Intergenic	TTC34
chr1:161411315–161,417,356	6041	980.0181	0.059054185	0.043507	Exon	FCGR2A
chr1:227165108–227,167,121	2013	321.0379	−0.05472419	0.043507	Promoter (<=1 kb)	ADCK3
chr10:42639382–42,642,799	3417	471.9378	0.053591881	0.043507	Distal Intergenic	LOC441666
chr12:117759233–117,761,187	1954	733.3737	−0.051097394	0.043507	Intron	NOS1
chr12:131743021–131,745,096	2075	402.1728	−0.04241032	0.043507	Distal Intergenic	LINC01257
chr14:104680716–104,682,479	1763	393.9317	−0.039036454	0.043507	Distal Intergenic	KIF26A
chr14:106130890–106,133,431	2541	327.5869	−0.050328469	0.043507	Intron	ELK2AP
chr18:9876–11,028	1152	869.3626	−0.058790034	0.043507	Distal Intergenic	ROCK1P1
chr2:90380982–90,382,232	1250	703.058	0.087608099	0.043507	Intron	MIR4436A
chr2:90390888–90,393,740	2852	1224.857	0.082639282	0.043507	Intron	MIR4436A
chr2:232245135–232,247,014	1879	684.5341	−0.049273959	0.043507	Distal Intergenic	B3GNT7
chr2:233878888–233,880,783	1895	458.8731	−0.042533652	0.043507	Promoter (<=1 kb)	NGEF
chr21:47233703–47,236,436	2733	660.0114	−0.045879449	0.043507	Intron	LOC100129027
chr22:28043663–28,045,838	2175	319.4394	−0.045382128	0.043507	Distal Intergenic	MN1
chr3:185842547–185,844,972	2425	338.0063	−0.040820001	0.043507	Distal Intergenic	ETV5
chr4:3679282–3,681,125	1843	632.2126	−0.039394589	0.043507	Promoter (<=1 kb)	LOC100133461
chr5:171997237–171,998,674	1437	574.0105	−0.040752286	0.043507	Distal Intergenic	NEURL1B
chr5:172145042–172,146,642	1600	283.15	−0.039405643	0.043507	Distal Intergenic	DUSP1
chr7:35083300–35,086,409	3109	667.0347	−0.063938851	0.043507	Exon	DPY19L1
chr8:27426562–27,428,394	1832	618.5586	−0.046453345	0.043507	Distal Intergenic	CLU
chrX:148615982–148,617,887	1905	496.8346	−0.071187463	0.043507	Promoter (<=1 kb)	IDS
chr14:77322208–77,324,017	1809	358.4726	−0.036853715	0.043857	Exon	LRRC74A
chr14:94213175–94,214,970	1795	274.9046	−0.044559973	0.043963	Intron	PRIMA1
chr8:143824284–143,827,190	2906	872.6112	−0.056328342	0.043963	Promoter (<=1 kb)	SLURP1
chr2:92289472–92,292,822	3350	4738.836	0.085456146	0.04533	Distal Intergenic	ACTR3BP2
chr1:15170988–15,172,589	1601	341.8562	−0.043070132	0.045985	Intron	KAZN
chr1:22873178–22,875,162	1984	628.9255	−0.048195935	0.045985	Distal Intergenic	EPHA8
chr15:32781660–32,783,301	1641	391.2485	−0.044570446	0.045985	Distal Intergenic	GOLGA8O
chr2:92294963–92,300,499	5536	4633.964	0.085605878	0.048908	Distal Intergenic	ACTR3BP2
chr4:5852906–5,854,271	1365	315.8726	−0.042689188	0.048908	Exon	CRMP1
chr7:15223273–15,225,157	1884	555.7869	−0.050035386	0.048908	Distal Intergenic	DGKB

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