Table 1 Medical history timeline where auxological parameters during the first 2 years of life and biochemical and hormonal values are summarized.
Chronologic Age (years) | 38 + 2 weeks of GA (Birth) | 40 + 2 weeks of GA (hospital admission) | 0.3 | 0.47 | 0.6 | 0.8 | 1.2 | 1.77 | 2.1 |
|---|---|---|---|---|---|---|---|---|---|
Length (cm) (°p)a | / | / | 57.6 (1.6) | 62.3 (1.5) | 65.9 (5) | 70 (10) | 76 (16) | 82.6 (17) | 85.3 (18) |
Weight (Kg) (°p)a | 2.505 (5) | 2.450 (<< 3) | 4.81 (< 3) | 5.66 (< 3) | 6.46 (< 3) | 7.51 (3–10) | 9.47 (47) | 11 (57) | 12.2 (53) |
Head Circumference (cm) | / | / | 39 | 41 | 42.5 | 44 | 46 | 47 | 48 |
Pubertal Stage (testicular volume) | / | P1,G1,A0 (1 ml bilateral) | P1,G1,A0 (1 ml bilateral) | P1,G1,A0 (1 ml bilateral) | P1,G1,A0 (1 ml bilateral) | P1,G1,A0 (1 ml bilateral) | P1,G1,A0 (1 ml bilateral) | P1,G1,A0 (2 ml bilateral) | P1,G1,A0 (2 ml bilateral) |
ACTH (pg/ml) | / | 91.4 | / | 124.9 | / | 300 | 83.1 | 40.6 | 81.6 |
Cortisol | / | 13.7 | / | 4.4 | 5.2 | 7.4 | 19.4 | 13.2 | 19.5 |
Aldosterone (pg/ml) | / | 38.6 | / | 55.9 | 45.2 | 21.5 | 16.7 | 16.4 | 15.2 |
Renin (μU/ml) | / | 44,100 | / | 181.2 | / | 123.6 | 5.6 | 2.5 | 23.4 |
17 OH progesterone (ng/ml) | / | 4.4 | / | / | / | 0.4 | / | 0.1 | 0.1 |
Na (mEq/L) | / | 110 | 138 | 134 | 139 | 139 | 140 | 138 | 139 |
K (mEq/L) | / | 7.5 | 5.7 | 4.9 | 5 | 4.2 | 4.8 | 4.5 | 4.3 |
DHEA-S (μg/ml) | / | 1.09 | / | / | / | 0.03 | / | < 0.02 | < 0.02 |
Testosterone (ng/ml) | / | / | / | / | / | 0.2 | / | / | < 0.1 |
Treatment | / | Fludro-cortisone 50 mcg/day + NaCl 11.6% 1 ml × 7/day | Fludro-cortisone 100 mcg/day + NaCl11.6% 1 ml × 7/day | Fludro-cortisone 100 mcg/day + NaCl11.6% 1 ml × 7/day | Fludro-cortisone 100 mcg/day + NaCl11.6% 1 ml × 7/day | Started Hydro-cortisone 10 mg/m2/day +Fludro-cortisone 100 mcg/day + NaCl11.6% 1 ml × 7/day | Hydro-cortisone 10 mg/m2/day + Fludro-cortisone 100 mcg/day + NaCl11.6% 1 ml × 7/day | Hydro-cortisone 10 mg/m2/day +Fludro-cortisone 100 mcg/day + NaCl11.6% 1 ml × 7/day | Hydro-cortisone 10 mg/m2/day +Fludro-cortisone 100 mcg/day + NaCl11.6% 1 ml × 7/day |