A novel risk score system for assessment of ovarian cancer based on co-expression network analysis and expression level of five lncRNAs

Zhao, Qian; Fan, Conghong

doi:10.1186/s12881-019-0832-9

Table 4 KEGG pathways significantly related to blue, green and yellow modules

From: A novel risk score system for assessment of ovarian cancer based on co-expression network analysis and expression level of five lncRNAs

Module/lncRNA	Name	ES	NES	NOM p-val	FDR q-val	Gene
Yellow/GAS5, SNHG5	Pyrimidine Metabolism	−0.461	−1.349	< 0.001	< 0.001	TYMP, UPP1, RRM2, NME4, NME5
	Regulation Of Actin Cytoskeleton	0.365	1.167	0.002	0.006	WAS, VAV1, ITGB2, ITGAL, NCKAP1L, ITGB6, MYLPF, ITGA7
	Fc Gamma R Mediated Phagocytosis	0.388	1.153	< 0.001	0.006	WAS, VAV1, FCGR3A, INPP5D, PTPRC, FCGR2A, FCGR2B,
	JAK STAT Signaling Pathway	0.404	1.153	< 0.001	0.008	CSF3R, IL2RG, IL6R, IL4R, IL10RA, OSM, OSMR, IL2RB
	Ribosome	−0.971	−1.156	< 0.001	0.028	RPS17, RPL39, RPL27A, RPL22L1, RPS20
Blue/HCP5 SNHG11	Endocytosis	−0.328	−1.593	< 0.001	< 0.001	HLA-B, HLA-C, HLA-A, HLA-F, TFRC, IL2RG, LDLR, HLA-G, IL2RB, SMAP2
	Antigen Processing and Presentation	−0.271	−1.695	< 0.001	< 0.001	CTSS, HLA-B, HLA-C, HLA-A, HLA-F, HLA-DMA, B2M, HLA-DPA1, HLA-DRB5, TAP2, TAP1, HLA-DPB1, HLA-DRA, HLA-DRB1
	Lysosome	−0.664	−1.846	< 0.001	< 0.001	CTSS, TCIRG1, LAMP3, LAPTM5, CD68
	Pathways in Cancer	0.488	1.653	< 0.001	< 0.001	CSF3R, RASSF5, FZD3, CDKN2B, MMP9, BIRC3
	Focal Adhesion	0.435	1.432	< 0.001	< 0.001	VAV1, MYLPF, ITGB6, ITGA7, BIRC3
	Fc Gamma R Mediated Phagocytosis	−0.324	−1.127	< 0.001	0.049	WAS, FCGR3A, INPP5D, RAC2, PTPRC, FCGR2A, FCGR2B, VAV1
	JAK STAT Signaling Pathway	0.418	1.222	< 0.001	0.002	CSF3R, IL2RG, IL6R, IL4R, IL10RA, OSM, OSMR, IL2RB
	Pyrimidine Metabolism	−0.497	−1.451	< 0.001	< 0.001	TYMP, UPP1, RRM2, NME4, NME5
Green/PART1	Pyrimidine Metabolism	−0.530	−1.520	0.001	0.004	RRM2, NME4, NME5, TYMP, UPP1
	Fc Gamma R Mediated Phagocytosis	0.402	1.239	0.003	0.012	VAV1, PTPRC, WAS, FCGR3A, FCGR2A, INPP5D, FCGR2B
	B Cell Receptor Signaling Pathway	0.469	1.186	0.007	0.016	VAV1, BLNK, INPP5D, FCGR2B
	T Cell Receptor Signaling Pathway	0.528	1.117	0.015	0.033	VAV1, PTPRC, CD3E, CD3D, TNF, CD8A, LCP2
	Pathways in Cancer	0.320	1.247	0.004	0.013	CDKN2B, CSF3R, MMP9, RASSF5, BIRC3

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