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Table 3 Genetic association results for metabolic syndrome component traits in females. Overall association results were obtained from meta-analyses combining KARE, Rural1816, Rural3667, and HEXA studies

From: Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females

Trait CHR SNP BP (GRCh37) Candidate gene EA EAF Overall meta (female) Overall meta (male) Overall meta (male+female) Association with MetS
BETA SE P meta P Het N BETA SE P meta BETA SE P meta P KARE-female
Genetic loci showing strong evidence of association for MetS component traits in females (Pmeta < 5X10−8)
 FPG 21 rs455489 41,939,569 DSCAM C 0.02 6.76 1.14 2.92E-09 0.53 7442 0.51 1.42 7.18E-01 4.03 0.91 9.14E-06 7.07E-02
 HDLC 11 rs7115583 116,784,376 SIK3 T 0.15 1.32 0.24 3.58E-08 0.20 6905 0.46 0.27 8.79E-02 0.94 0.18 2.30E-07 1.61E-01
Genetic loci showing moderate evidence of association for MetS component traits in females (5X10− 8 < Pmeta < 10−5)
 WC 1 rs6683379 223,906,421 CAPN2 A 0.48 −0.65 0.14 8.05E-06 0.88 6690 0.09 0.14 5.11E-01 − 0.35 0.11 9.53E-04 3.44E-01
8 rs921449 34,967,179 LOC105379369 A 0.32 0.58 0.13 9.29E-06 0.74 9819 −0.08 0.13 5.31E-01 0.27 0.10 6.65E-03 6.88E-01
20 rs6029818 40,409,163 CHD6 A 0.24 0.63 0.14 8.47E-06 0.85 9779 0.04 0.14 7.58E-01 0.30 0.11 4.43E-03 3.20E-01
 FPG 2 rs10171377 77,437,279 LRRTM4 G 0.31 −1.13 0.25 8.19E-06 0.54 6556 −0.16 0.32 6.28E-01 − 0.68 0.20 6.98E-04 6.93E-01
3 rs6801331 124,918,754 SLC12A8 T 0.11 1.59 0.36 8.45E-06 0.87 9786 0.30 0.46 5.16E-01 1.04 0.29 2.97E-04 1.10E-02
8 rs7821492 77,823,083 ZFHX4/PEX2 C 0.02 8.02 1.56 2.77E-07 0.13 7202 2.06 1.76 2.42E-01 5.33 1.19 7.33E-06 5.50E-01
10 rs12783001 65,091,110 JMJD1C C 0.02 6.81 1.50 5.36E-06 0.55 7481 1.37 1.69 4.16E-01 4.32 1.14 1.52E-04 8.35E-01
11 rs571911 126,481,440 KIRREL3 C 0.42 −1.76 0.37 1.94E-06 0.50 7497 −0.28 0.43 5.13E-01 −1.13 0.29 7.87E-05 8.41E-01
12 rs17125610 62,392,548 FAM19A2 A 0.10 2.59 0.58 9.33E-06 0.95 7453 −0.26 0.70 7.11E-01 1.25 0.46 6.23E-03 6.18E-01
 SBP 5 rs10474306 89,069,875 LOC105379076 G 0.14 1.70 0.38 9.37E-06 0.72 7531 −0.29 0.39 4.60E-01 0.78 0.28 5.19E-03 1.29E-01
5 rs316224 96,414,272 LIX1-AS1 A 0.29 1.30 0.29 9.72E-06 0.76 7660 −0.17 0.30 5.61E-01 0.65 0.21 2.06E-03 3.90E-01
6 rs393628 5,109,119 LYRM4 T 0.09 1.97 0.44 7.75E-06 0.83 6657 0.11 0.48 8.19E-01 1.20 0.33 2.67E-04 4.14E-01
7 rs4419754 79,337,748 LOC105375370 C 0.05 −2.86 0.58 7.30E-07 0.66 6700 −0.53 0.62 3.91E-01 −1.78 0.43 3.20E-05 1.94E-01
15 rs16973236 82,235,114 LOC102724001 G 0.17 1.69 0.38 7.20E-06 0.62 6668 0.23 0.40 5.68E-01 0.99 0.28 3.72E-04 6.21E-02
17 rs3888658 64,473,272 PRKCA A 0.31 −1.30 0.29 7.17E-06 1.00 7657 0.37 0.30 2.09E-01 −0.51 0.21 1.45E-02 5.46E-01
 DBP 12 rs7315532 9,483,063 LOC105369649 C 0.37 0.79 0.18 9.89E-06 0.81 7654 −0.11 0.19 5.65E-01 0.40 0.13 2.17E-03 4.30E-01
14 rs2415841 44,650,411 LINC02307 C 0.05 1.82 0.39 2.21E-06 0.82 6647 −0.09 0.43 8.36E-01 1.04 0.29 4.06E-04 4.17E-01
16 rs1364120 83,740,126 CDH13 G 0.32 −0.77 0.17 6.30E-06 0.80 6904 −0.02 0.20 9.10E-01 −0.43 0.13 1.06E-03 2.21E-01
 HDLC 11 rs11216315 117,080,640 PCSK7 G 0.13 1.17 0.26 6.87E-06 0.78 7649 0.39 0.28 1.64E-01 0.82 0.19 1.84E-05 6.30E-01
13 rs4883839 69,720,694 na T 0.28 0.85 0.19 7.87E-06 0.29 7633 0.14 0.20 4.92E-01 0.51 0.14 2.71E-04 1.53E-02
16 rs6497373 19,460,842 TMC5 A 0.16 −1.04 0.23 8.45E-06 0.46 7650 0.02 0.25 9.31E-01 −0.61 0.17 4.15E-04 5.78E-01
18 rs11082766 47,132,464 LIPG T 0.27 0.96 0.19 6.89E-07 0.27 7649 0.24 0.21 2.45E-01 0.60 0.14 3.39E-05 6.26E-01
19 rs6508974 41,733,145 AXL C 0.37 0.87 0.18 1.09E-06 0.63 7652 −0.06 0.19 7.39E-01 0.44 0.13 8.21E-04 3.74E-03
20 rs6046295 19,727,038 SLC24A3/RIN2 A 0.05 1.58 0.35 4.40E-06 0.11 9819 −0.34 0.39 3.89E-01 0.66 0.26 1.12E-02 1.13E-01
 TG 1 rs3766235 47,049,747 MKNK1 C 0.03 17.81 3.95 6.57E-06 0.30 6893 3.46 6.86 6.15E-01 11.45 3.72 2.08E-03 7.11E-01
1 rs11208004 63,145,439 DOCK7 A 0.17 −8.10 1.82 9.13E-06 0.42 6730 −5.56 2.98 6.19E-02 −7.30 1.67 1.27E-05 7.06E-01
5 rs1092913 10,467,702 ROPN1L G 0.29 7.54 1.46 2.33E-07 0.32 7658 1.69 2.26 4.54E-01 5.08 1.34 1.49E-04 2.09E-01
6 rs3132722 29,867,174 LOC105375010 T 0.26 6.90 1.54 7.61E-06 0.81 6629 4.63 2.51 6.48E-02 6.17 1.42 1.37E-05 2.60E-01
9 rs1381151 24,957,550 na A 0.12 9.14 2.05 8.24E-06 0.56 6876 −0.75 3.35 8.24E-01 4.84 1.89 1.02E-02 8.20E-01
12 rs710698 70,369,918 MYRFL G 0.30 6.85 1.49 4.34E-06 0.52 6664 3.58 2.44 1.42E-01 5.62 1.37 4.27E-05 1.88E-01
14 rs17124780 52,425,506 GNG2 G 0.29 −6.73 1.24 5.52E-08 0.33 9920 −1.09 2.02 5.87E-01 −4.35 1.15 1.55E-04 6.47E-01
16 rs179604 13,814,473 SHISA9/ERCC4 T 0.49 −5.89 1.33 9.47E-06 0.16 7655 0.76 2.05 7.12E-01 −2.73 1.22 2.48E-02 1.58E-01
22 rs1065314 33,258,288 SYN3/TIMP3 C 0.06 14.58 2.82 2.41E-07 0.44 6738 0.62 4.55 8.92E-01 8.12 2.57 1.61E-03 3.48E-01
  1. Information for the SNP ID and chromosomal position is based on NCBI genome build 37/hg19
  2. CHR chromosome, BP Physical position (base-pair), EA effect allele, EAF effect allele frequency, SE standard error, PHet heterogeneity p-value, N sample size, WC waist circumference, FPG fasting plasma glucose, SBP systolic blood presure, DBP diastolic blood presure, HDLC high density lipoprotein cholesterol, TG triglyceride