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Table 3 Genetic association results for metabolic syndrome component traits in females. Overall association results were obtained from meta-analyses combining KARE, Rural1816, Rural3667, and HEXA studies

From: Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females

Trait

CHR

SNP

BP (GRCh37)

Candidate gene

EA

EAF

Overall meta (female)

Overall meta (male)

Overall meta (male+female)

Association with MetS

BETA

SE

P meta

P Het

N

BETA

SE

P meta

BETA

SE

P meta

P KARE-female

Genetic loci showing strong evidence of association for MetS component traits in females (Pmeta < 5X10−8)

 FPG

21

rs455489

41,939,569

DSCAM

C

0.02

6.76

1.14

2.92E-09

0.53

7442

0.51

1.42

7.18E-01

4.03

0.91

9.14E-06

7.07E-02

 HDLC

11

rs7115583

116,784,376

SIK3

T

0.15

1.32

0.24

3.58E-08

0.20

6905

0.46

0.27

8.79E-02

0.94

0.18

2.30E-07

1.61E-01

Genetic loci showing moderate evidence of association for MetS component traits in females (5X10− 8 < Pmeta < 10−5)

 WC

1

rs6683379

223,906,421

CAPN2

A

0.48

−0.65

0.14

8.05E-06

0.88

6690

0.09

0.14

5.11E-01

− 0.35

0.11

9.53E-04

3.44E-01

8

rs921449

34,967,179

LOC105379369

A

0.32

0.58

0.13

9.29E-06

0.74

9819

−0.08

0.13

5.31E-01

0.27

0.10

6.65E-03

6.88E-01

20

rs6029818

40,409,163

CHD6

A

0.24

0.63

0.14

8.47E-06

0.85

9779

0.04

0.14

7.58E-01

0.30

0.11

4.43E-03

3.20E-01

 FPG

2

rs10171377

77,437,279

LRRTM4

G

0.31

−1.13

0.25

8.19E-06

0.54

6556

−0.16

0.32

6.28E-01

− 0.68

0.20

6.98E-04

6.93E-01

3

rs6801331

124,918,754

SLC12A8

T

0.11

1.59

0.36

8.45E-06

0.87

9786

0.30

0.46

5.16E-01

1.04

0.29

2.97E-04

1.10E-02

8

rs7821492

77,823,083

ZFHX4/PEX2

C

0.02

8.02

1.56

2.77E-07

0.13

7202

2.06

1.76

2.42E-01

5.33

1.19

7.33E-06

5.50E-01

10

rs12783001

65,091,110

JMJD1C

C

0.02

6.81

1.50

5.36E-06

0.55

7481

1.37

1.69

4.16E-01

4.32

1.14

1.52E-04

8.35E-01

11

rs571911

126,481,440

KIRREL3

C

0.42

−1.76

0.37

1.94E-06

0.50

7497

−0.28

0.43

5.13E-01

−1.13

0.29

7.87E-05

8.41E-01

12

rs17125610

62,392,548

FAM19A2

A

0.10

2.59

0.58

9.33E-06

0.95

7453

−0.26

0.70

7.11E-01

1.25

0.46

6.23E-03

6.18E-01

 SBP

5

rs10474306

89,069,875

LOC105379076

G

0.14

1.70

0.38

9.37E-06

0.72

7531

−0.29

0.39

4.60E-01

0.78

0.28

5.19E-03

1.29E-01

5

rs316224

96,414,272

LIX1-AS1

A

0.29

1.30

0.29

9.72E-06

0.76

7660

−0.17

0.30

5.61E-01

0.65

0.21

2.06E-03

3.90E-01

6

rs393628

5,109,119

LYRM4

T

0.09

1.97

0.44

7.75E-06

0.83

6657

0.11

0.48

8.19E-01

1.20

0.33

2.67E-04

4.14E-01

7

rs4419754

79,337,748

LOC105375370

C

0.05

−2.86

0.58

7.30E-07

0.66

6700

−0.53

0.62

3.91E-01

−1.78

0.43

3.20E-05

1.94E-01

15

rs16973236

82,235,114

LOC102724001

G

0.17

1.69

0.38

7.20E-06

0.62

6668

0.23

0.40

5.68E-01

0.99

0.28

3.72E-04

6.21E-02

17

rs3888658

64,473,272

PRKCA

A

0.31

−1.30

0.29

7.17E-06

1.00

7657

0.37

0.30

2.09E-01

−0.51

0.21

1.45E-02

5.46E-01

 DBP

12

rs7315532

9,483,063

LOC105369649

C

0.37

0.79

0.18

9.89E-06

0.81

7654

−0.11

0.19

5.65E-01

0.40

0.13

2.17E-03

4.30E-01

14

rs2415841

44,650,411

LINC02307

C

0.05

1.82

0.39

2.21E-06

0.82

6647

−0.09

0.43

8.36E-01

1.04

0.29

4.06E-04

4.17E-01

16

rs1364120

83,740,126

CDH13

G

0.32

−0.77

0.17

6.30E-06

0.80

6904

−0.02

0.20

9.10E-01

−0.43

0.13

1.06E-03

2.21E-01

 HDLC

11

rs11216315

117,080,640

PCSK7

G

0.13

1.17

0.26

6.87E-06

0.78

7649

0.39

0.28

1.64E-01

0.82

0.19

1.84E-05

6.30E-01

13

rs4883839

69,720,694

na

T

0.28

0.85

0.19

7.87E-06

0.29

7633

0.14

0.20

4.92E-01

0.51

0.14

2.71E-04

1.53E-02

16

rs6497373

19,460,842

TMC5

A

0.16

−1.04

0.23

8.45E-06

0.46

7650

0.02

0.25

9.31E-01

−0.61

0.17

4.15E-04

5.78E-01

18

rs11082766

47,132,464

LIPG

T

0.27

0.96

0.19

6.89E-07

0.27

7649

0.24

0.21

2.45E-01

0.60

0.14

3.39E-05

6.26E-01

19

rs6508974

41,733,145

AXL

C

0.37

0.87

0.18

1.09E-06

0.63

7652

−0.06

0.19

7.39E-01

0.44

0.13

8.21E-04

3.74E-03

20

rs6046295

19,727,038

SLC24A3/RIN2

A

0.05

1.58

0.35

4.40E-06

0.11

9819

−0.34

0.39

3.89E-01

0.66

0.26

1.12E-02

1.13E-01

 TG

1

rs3766235

47,049,747

MKNK1

C

0.03

17.81

3.95

6.57E-06

0.30

6893

3.46

6.86

6.15E-01

11.45

3.72

2.08E-03

7.11E-01

1

rs11208004

63,145,439

DOCK7

A

0.17

−8.10

1.82

9.13E-06

0.42

6730

−5.56

2.98

6.19E-02

−7.30

1.67

1.27E-05

7.06E-01

5

rs1092913

10,467,702

ROPN1L

G

0.29

7.54

1.46

2.33E-07

0.32

7658

1.69

2.26

4.54E-01

5.08

1.34

1.49E-04

2.09E-01

6

rs3132722

29,867,174

LOC105375010

T

0.26

6.90

1.54

7.61E-06

0.81

6629

4.63

2.51

6.48E-02

6.17

1.42

1.37E-05

2.60E-01

9

rs1381151

24,957,550

na

A

0.12

9.14

2.05

8.24E-06

0.56

6876

−0.75

3.35

8.24E-01

4.84

1.89

1.02E-02

8.20E-01

12

rs710698

70,369,918

MYRFL

G

0.30

6.85

1.49

4.34E-06

0.52

6664

3.58

2.44

1.42E-01

5.62

1.37

4.27E-05

1.88E-01

14

rs17124780

52,425,506

GNG2

G

0.29

−6.73

1.24

5.52E-08

0.33

9920

−1.09

2.02

5.87E-01

−4.35

1.15

1.55E-04

6.47E-01

16

rs179604

13,814,473

SHISA9/ERCC4

T

0.49

−5.89

1.33

9.47E-06

0.16

7655

0.76

2.05

7.12E-01

−2.73

1.22

2.48E-02

1.58E-01

22

rs1065314

33,258,288

SYN3/TIMP3

C

0.06

14.58

2.82

2.41E-07

0.44

6738

0.62

4.55

8.92E-01

8.12

2.57

1.61E-03

3.48E-01

  1. Information for the SNP ID and chromosomal position is based on NCBI genome build 37/hg19
  2. CHR chromosome, BP Physical position (base-pair), EA effect allele, EAF effect allele frequency, SE standard error, PHet heterogeneity p-value, N sample size, WC waist circumference, FPG fasting plasma glucose, SBP systolic blood presure, DBP diastolic blood presure, HDLC high density lipoprotein cholesterol, TG triglyceride
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BMC Medical Genetics

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