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Table 2 Metabolic syndrome (MetS) associated loci in females. Discovery stage was GWAS for MetS in each sex-stratified group of KARE study. Overall association results (Pmeta) were obtained from meta-analyses combining Discover (KARE) and Replication (Rural1816, Rural3667 and HEXA) stages

From: Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females

CHR SNP BP (GRCh37) Candidate gene EA EAF Female Male Combining female & male
Discovery Replication Overall
KARE Rural1816 Rural3667 HEXA
OR PKARE OR PRural1816 OR PRural3667 OR PHEXA OR Pmeta N OR Pmeta N OR Pmeta N
1 rs2209363 187,163,851 LINC01036 C 0.18 0.67 5.32E-04 0.72 1.27E-02 0.69 2.11E-05 2496 1.08 3.64E-01 1870 0.88 4.24E-02 4366
2 rs768072 160,233,383 BAZ2B T 0.25 0.72 7.66E-04 0.72 1.08E-02 0.72 2.41E-05 2596 0.96 5.72E-01 1922 0.82 2.34E-04 4518
2 rs284544 217,309,111 SMARCAL1 A 0.21 1.51 1.65E-04 1.36 1.77E-02 1.44 1.06E-05 2572 0.97 7.25E-01 1907 1.15 1.01E-02 4479
2 rs284541 217,368,839 RPL37A T 0.20 1.51 2.56E-04 1.34 2.90E-02 1.43 2.66E-05 2531 0.92 3.28E-01 1879 1.12 4.59E-02 4410
2 rs2012243 217,412,087 LOC101928180 A 0.21 1.50 1.77E-04 1.30 3.98E-02 1.41 2.77E-05 2599 0.93 3.59E-01 1924 1.11 6.45E-02 4523
6 rs10947646 36,881,535 C6orf89 G 0.02 0.33 2.66E-04 0.35 4.97E-02 0.34 3.46E-05 3196 1.48 9.18E-02 2353 0.78 1.28E-01 5549
8 rs2283113 17,880,243 PCM1 A 0.47 1.32 1.42E-03 1.31 1.15E-02 1.31 4.77E-05 2524 1.07 3.10E-01 1869 1.18 3.61E-04 4393
9 rs16923249 5,592,145 PDCD1LG2-RIC1 A 0.03 0.44 4.26E-04 0.39 2.89E-02 0.43 3.46E-05 3214 1.02 9.29E-01 2360 0.73 1.28E-02 5574
13 rs9568558 51,810,953 FAM124A G 0.26 1.33 4.77E-03 1.39 1.11E-02 1.24 1.15E-01 1.32 4.98E-05 3436 0.99 8.60E-01 2466 1.13 9.69E-03 5902
13 rs9516416 95,103,694 DCT C 0.13 0.68 2.96E-03 0.68 3.71E-01 0.55 2.16E-03 0.64 2.04E-05 3166 1.00 9.64E-01 2325 0.82 4.17E-03 5491
13 rs6492111 109,055,846 TNFSF13B-MYO16 C 0.02 0.35 3.83E-03 0.96 9.66E-01 0.31 1.74E-03 0.35 3.47E-05 3176 0.75 2.91E-01 2325 0.54 7.51E-04 5501
16 rs4072617 20,178,590 GPR139 A 0.19 1.36 3.83E-03 1.41 4.70E-01 1.36 3.02E-02 1.54 2.91E-03 1.41 2.84E-06 3954 0.97 6.36E-01 2857 1.15 4.09E-03 6811
19 rs8107274 37,285,393 ZNF790 C 0.03 4.56 5.27E-04 2.26 1.34E-02 2.91 4.92E-05 2579 0.85 4.67E-01 1908 1.40 2.94E-02 4487
21 rs2827976 24,600,783 LOC105372747 G 0.19 0.69 5.47E-04 0.61 1.50E-01 0.72 3.74E-02 0.70 1.99E-05 3205 0.97 6.87E-01 2357 0.83 8.28E-04 5562
  1. Information for the SNP ID and chromosomal position is based on NCBI genome build 37/hg19
  2. The ‘-’ sign indicates data not available
  3. CHR chromosome, BP Physical position (base-pair), EA effect allele, EAF effect allele frequency, OR Odds Ratio, N sample size of meta-analysis combining cases and controls