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Table 3 Genotype and allele frequencies of the studied SNPs in patients with chronic HBV infection

From: Association of NTCP polymorphisms with clinical outcome of hepatitis B infection in Thai individuals

Polymorphisms The non-HCC group (n = 305) The HCC group (n = 305) HCC vs. non-HCC
OR (95% CI) P
rs2296651
 Genotype frequency
  GG 252 (82.6) 273 (89.5) 1
  GA 48 (15.7) 27 (8.9) 0.52 (0.31–0.86) 0.010* 0.009a
  AA 5 (1.6) 5 (1.6) 0.92 (0.26–3.23) 0.900
  GA + AA 53 (17.3) 32 (10.5) 0.56 (0.35–0.89) 0.015* 0.015a
 Allele frequency
  G 552 (90.5) 573 (93.9) 1
  A 58 (9.5) 37 (6.1) 0.61 (0.40–0.94) 0.026* 0.029a
rs4646287     
 Genotype frequency
  CC 254 (83.3) 241 (79.0) 1
  CT 42 (13.8) 61 (20.0) 1.53 (1.00–2.35) 0.053
  TT 9 (3.0) 3 (1.0) 0.35 (0.09–1.31) 0.120
  CT + TT 51 (16.8) 64 (21.0) 1.33 (0.88–1.99) 0.180
 Allele frequency
  C 550 (90.2) 543 (89.0) 1
  T 60 (9.8) 67 (11.0) 1.13 (0.78–1.63) 0.512
  1. Data expressed as n (%), OR odds ratio, CI confidence interval, *Crude P-value, aP-value (adjusted for age and sex)