Table 3 Genotype and allele frequencies of the studied SNPs in patients with chronic HBV infection
From: Association of NTCP polymorphisms with clinical outcome of hepatitis B infection in Thai individuals
Polymorphisms | The non-HCC group (n = 305) | The HCC group (n = 305) | HCC vs. non-HCC | |
|---|---|---|---|---|
OR (95% CI) | P | |||
rs2296651 | ||||
Genotype frequency | ||||
GG | 252 (82.6) | 273 (89.5) | 1 | – |
GA | 48 (15.7) | 27 (8.9) | 0.52 (0.31–0.86) | 0.010* 0.009a |
AA | 5 (1.6) | 5 (1.6) | 0.92 (0.26–3.23) | 0.900 |
GA + AA | 53 (17.3) | 32 (10.5) | 0.56 (0.35–0.89) | 0.015* 0.015a |
Allele frequency | ||||
G | 552 (90.5) | 573 (93.9) | 1 | – |
A | 58 (9.5) | 37 (6.1) | 0.61 (0.40–0.94) | 0.026* 0.029a |
rs4646287 | ||||
Genotype frequency | ||||
CC | 254 (83.3) | 241 (79.0) | 1 | – |
CT | 42 (13.8) | 61 (20.0) | 1.53 (1.00–2.35) | 0.053 |
TT | 9 (3.0) | 3 (1.0) | 0.35 (0.09–1.31) | 0.120 |
CT + TT | 51 (16.8) | 64 (21.0) | 1.33 (0.88–1.99) | 0.180 |
Allele frequency | ||||
C | 550 (90.2) | 543 (89.0) | 1 | – |
T | 60 (9.8) | 67 (11.0) | 1.13 (0.78–1.63) | 0.512 |