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Table 2 Genotype and allele frequencies of the studied SNPs in all groups

From: Association of NTCP polymorphisms with clinical outcome of hepatitis B infection in Thai individuals

Polymorphisms Healthy Controls (n = 205) Spontaneous Clearance (n = 206) Chronic HBV Infection (n = 610) Chronic HBV infection vs. Healthy Controls Chronic HBV infection vs. Spontaneous Clearance Spontaneous Clearance vs. Healthy Controls
OR (95% CI) P OR (95% CI) P OR (95% CI) P
rs2296651
 Genotype frequency
  GG 150 (73.1) 177 (85.9) 525 (86.1) 1 1 1
  GA 53 (25.9) 28 (13.6) 75 (12.3) 0.40 (0.27–0.60) < 0.001* < 0.001a 0.90 (0.57–1.44) 0.668 0.45 (0.27–0.74) 0.002* 0.001a
  AA 2 (1.0) 1 (0.5) 10 (1.6) 1.43 (0.31–6.59) 0.648 3.37 (0.43–26.52) 0.248 0.42 (0.38–4.72) 0.485
  GA + AA 55 (26.9) 29 (14.1) 85 (13.9) 0.44 (0.30–0.65) < 0.001* < 0.001a 0.99 (0.63–1.56) 0.959 0.45 (0.27–0.74) 0.002* 0.001a
 Allele frequency
  G 353 (86.1) 382 (92.7) 1125 (92.2) 1 1   1
  A 57 (13.9) 30 (7.3) 95 (7.8) 0.48 (0.34–0.69) < 0.001* 0.001a 1.08 (0.70–1.65) 0.739 0.49 (0.31–0.77) 0.002* 0.002a
rs4646287
 Genotype frequency
  CC 168 (82.0) 175 (85.0) 495 (81.1) 1 1   1
  CT 35 (17.0) 29 (14.0) 103 (16.9) 1.00 (0.66–1.52) 0.996 1.26 (0.80–1.96) 0.318 0.80 (0.47–1.36) 0.402
  TT 2 (1.0) 2 (1.0) 12 (2.0) 2.04 (0.45–9.19) 0.355 2.12 (0.47–9.57) 0.328 0.96 (0.13–6.89) 0.968
  CT + TT 37 (18.0) 31 (15.0) 115 (18.9) 1.05 (0.70–1.59) 0.798 1.31 (0.85–2.02) 0.219 0.80 (0.48–1.36) 0.414
 Allele frequency
  C 371 (90.5) 379 (92.0) 1093 (89.6) 1 1   1
  T 39 (9.5) 33 (8.0) 127 (10.4) 1.11 (0.76–1.61) 0.603 1.33 (0.89–1.99) 0.158 0.83 (0.51–1.35) 0.447
  1. Data expressed as n (%), OR odds ratio, CI confidence interval, *Crude P-value, aP-value (adjusted for age and sex)