Table 2 Genotype and allele frequencies of the studied SNPs in all groups
From: Association of NTCP polymorphisms with clinical outcome of hepatitis B infection in Thai individuals
Polymorphisms | Healthy Controls (n = 205) | Spontaneous Clearance (n = 206) | Chronic HBV Infection (n = 610) | Chronic HBV infection vs. Healthy Controls | Chronic HBV infection vs. Spontaneous Clearance | Spontaneous Clearance vs. Healthy Controls | |||
|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||||
rs2296651 | |||||||||
Genotype frequency | |||||||||
GG | 150 (73.1) | 177 (85.9) | 525 (86.1) | 1 | – | 1 | – | 1 | – |
GA | 53 (25.9) | 28 (13.6) | 75 (12.3) | 0.40 (0.27–0.60) | < 0.001* < 0.001a | 0.90 (0.57–1.44) | 0.668 | 0.45 (0.27–0.74) | 0.002* 0.001a |
AA | 2 (1.0) | 1 (0.5) | 10 (1.6) | 1.43 (0.31–6.59) | 0.648 | 3.37 (0.43–26.52) | 0.248 | 0.42 (0.38–4.72) | 0.485 |
GA + AA | 55 (26.9) | 29 (14.1) | 85 (13.9) | 0.44 (0.30–0.65) | < 0.001* < 0.001a | 0.99 (0.63–1.56) | 0.959 | 0.45 (0.27–0.74) | 0.002* 0.001a |
Allele frequency | |||||||||
G | 353 (86.1) | 382 (92.7) | 1125 (92.2) | 1 | – | 1 | 1 | – | |
A | 57 (13.9) | 30 (7.3) | 95 (7.8) | 0.48 (0.34–0.69) | < 0.001* 0.001a | 1.08 (0.70–1.65) | 0.739 | 0.49 (0.31–0.77) | 0.002* 0.002a |
rs4646287 | |||||||||
Genotype frequency | |||||||||
CC | 168 (82.0) | 175 (85.0) | 495 (81.1) | 1 | – | 1 | 1 | – | |
CT | 35 (17.0) | 29 (14.0) | 103 (16.9) | 1.00 (0.66–1.52) | 0.996 | 1.26 (0.80–1.96) | 0.318 | 0.80 (0.47–1.36) | 0.402 |
TT | 2 (1.0) | 2 (1.0) | 12 (2.0) | 2.04 (0.45–9.19) | 0.355 | 2.12 (0.47–9.57) | 0.328 | 0.96 (0.13–6.89) | 0.968 |
CT + TT | 37 (18.0) | 31 (15.0) | 115 (18.9) | 1.05 (0.70–1.59) | 0.798 | 1.31 (0.85–2.02) | 0.219 | 0.80 (0.48–1.36) | 0.414 |
Allele frequency | |||||||||
C | 371 (90.5) | 379 (92.0) | 1093 (89.6) | 1 | – | 1 | 1 | – | |
T | 39 (9.5) | 33 (8.0) | 127 (10.4) | 1.11 (0.76–1.61) | 0.603 | 1.33 (0.89–1.99) | 0.158 | 0.83 (0.51–1.35) | 0.447 |