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Table 4 The assessment of heterogeneity and publication bias

From: Genetic impact of methylenetetrahydrofolate reductase (MTHFR) polymorphism on the susceptibility to colorectal polyps: a meta-analysis

polymorphism

Comparison

I2

P value

Model

Begg’s test

Egger’s test

z

P

t

P

rs1801133

allele T vs. allele C

0.0%

0.736

Fixed

0.69

0.492

0.46

0.651

TT vs. CC

0.0%

0.799

Fixed

0.90

0.367

0.75

0.463

CT vs. CC

0.0%

0.705

Fixed

0.79

0.428

−0.41

0.685

CT + TT vs. CC

0.0%

0.725

Fixed

0.11

0.916

−0.02

0.984

TT vs. CC + CT

0.0%

0.790

Fixed

0.73

0.463

0.70

0.492

carrier T vs. carrier C

0.0%

0.999

Fixed

0.32

0.751

0.27

0.787

rs1801131

allele C vs. allele A

9.6%

0.354

Fixed

1.16

0.245

1.41

0.195

CC vs. AA

14.3%

0.311

Fixed

1.52

0.128

1.96

0.085

AC vs. AA

0.0%

0.800

Fixed

0.45

0.655

−0.25

0.807

AC + CC vs. AA

0.0%

0.623

Fixed

1.34

0.180

0.64

0.541

CC vs. AA+AC

8.3%

0.366

Fixed

1.52

0.128

2.17

0.061

carrier C vs. carrier A

0.0%

0.918

Fixed

0.98

0.325

1.04

0.327