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Table 3 Pooled analysis for the MTHFR rs1801131 polymorphism

From: Genetic impact of methylenetetrahydrofolate reductase (MTHFR) polymorphism on the susceptibility to colorectal polyps: a meta-analysis

Comparison

Subgroup

Sample size

Test of association

Studies

case/control

RRs (95% CIs)

z

P

allele C vs. allele A

overall

10

2951/3527

1.05 (0.99, 1.11)

1.60

0.109

UK

5

1257/1407

1.08 (0.99, 1.17)

1.79

0.073

Caucasian

8

2225/2858

1.04 (0.98, 1.10)

1.22

0.222

adenomatous polyps

9

2934/3451

1.04 (0.99, 1.10)

1.48

0.138

CC vs. AA

overall

10

2951/3527

1.15 (0.98, 1.35)

1.69

0.091

UK

5

1257/1407

1.27 (1.02, 1.57)

2.14

0.032

Caucasian

8

2225/2858

1.14 (0.96, 1.35)

1.50

0.133

adenomatous polyps

9

2934/3451

1.14 (0.97, 1.34)

1.58

0.114

AC vs. AA

overall

10

2951/3527

1.02 (0.96, 1.08)

0.63

0.528

UK

5

1257/1407

1.02 (0.93, 1.11)

0.39

0.698

Caucasian

8

2225/2858

1.01 (0.95, 1.07)

0.25

0.805

adenomatous polyps

9

2934/3451

1.02 (0.96, 1.08)

0.56

0.576

AC + CC vs. AA

overall

10

2951/3527

1.03 (0.98, 1.08)

1.13

0.258

UK

5

1257/1407

1.04 (0.97, 1.12)

1.08

0.279

Caucasian

8

2225/2858

1.02 (0.97, 1.08)

0.72

0.471

adenomatous polyps

9

2934/3451

1.03 (0.98, 1.08)

1.03

0.303

CC vs. AA + AC

overall

10

2951/3527

1.15 (0.97, 1.36)

1.64

0.100

UK

5

1257/1407

1.27 (1.02, 1.60)

2.10

0.036

Caucasian

8

2225/2858

1.14 (0.96, 1.36)

1.49

0.135

adenomatous polyps

9

2934/3451

1.14 (0.97, 1.35)

1.55

0.122

carrier C vs. carrier A

overall

10

2951/3527

1.03 (0.97, 1.09)

0.96

0.336

UK

5

1257/1407

1.04 (0.96, 1.14)

1.00

0.318

Caucasian

8

2225/2858

1.02 (0.96, 1.09)

0.68

0.499

adenomatous polyps

9

2934/3451

1.03 (0.97, 1.09)

0.88

0.376

  1. PB Population-based control, HB Hospital-based control, RRs Risk ratios, CIs Confidence intervals
  2. Bold entries are significant