Skip to main content

Advertisement

Table 3 Pooled analysis for the MTHFR rs1801131 polymorphism

From: Genetic impact of methylenetetrahydrofolate reductase (MTHFR) polymorphism on the susceptibility to colorectal polyps: a meta-analysis

Comparison Subgroup Sample size Test of association
Studies case/control RRs (95% CIs) z P
allele C vs. allele A overall 10 2951/3527 1.05 (0.99, 1.11) 1.60 0.109
UK 5 1257/1407 1.08 (0.99, 1.17) 1.79 0.073
Caucasian 8 2225/2858 1.04 (0.98, 1.10) 1.22 0.222
adenomatous polyps 9 2934/3451 1.04 (0.99, 1.10) 1.48 0.138
CC vs. AA overall 10 2951/3527 1.15 (0.98, 1.35) 1.69 0.091
UK 5 1257/1407 1.27 (1.02, 1.57) 2.14 0.032
Caucasian 8 2225/2858 1.14 (0.96, 1.35) 1.50 0.133
adenomatous polyps 9 2934/3451 1.14 (0.97, 1.34) 1.58 0.114
AC vs. AA overall 10 2951/3527 1.02 (0.96, 1.08) 0.63 0.528
UK 5 1257/1407 1.02 (0.93, 1.11) 0.39 0.698
Caucasian 8 2225/2858 1.01 (0.95, 1.07) 0.25 0.805
adenomatous polyps 9 2934/3451 1.02 (0.96, 1.08) 0.56 0.576
AC + CC vs. AA overall 10 2951/3527 1.03 (0.98, 1.08) 1.13 0.258
UK 5 1257/1407 1.04 (0.97, 1.12) 1.08 0.279
Caucasian 8 2225/2858 1.02 (0.97, 1.08) 0.72 0.471
adenomatous polyps 9 2934/3451 1.03 (0.98, 1.08) 1.03 0.303
CC vs. AA + AC overall 10 2951/3527 1.15 (0.97, 1.36) 1.64 0.100
UK 5 1257/1407 1.27 (1.02, 1.60) 2.10 0.036
Caucasian 8 2225/2858 1.14 (0.96, 1.36) 1.49 0.135
adenomatous polyps 9 2934/3451 1.14 (0.97, 1.35) 1.55 0.122
carrier C vs. carrier A overall 10 2951/3527 1.03 (0.97, 1.09) 0.96 0.336
UK 5 1257/1407 1.04 (0.96, 1.14) 1.00 0.318
Caucasian 8 2225/2858 1.02 (0.96, 1.09) 0.68 0.499
adenomatous polyps 9 2934/3451 1.03 (0.97, 1.09) 0.88 0.376
  1. PB Population-based control, HB Hospital-based control, RRs Risk ratios, CIs Confidence intervals
  2. Bold entries are significant