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Table 2 Pooled analysis for the MTHFR rs1801133 polymorphism

From: Genetic impact of methylenetetrahydrofolate reductase (MTHFR) polymorphism on the susceptibility to colorectal polyps: a meta-analysis

Comparison Subgroup Sample size Test of association
Studies Case/control RRs (95% CIs) z P
allele T vs. allele C overall 23 8321/17,731 0.98 (0.95, 1.01) 1.42 0.156
UK 6 1353/1517 0.99 (0.92, 1.07) 0.14 0.886
USA 8 2863/4343 1.00 (0.95, 1.05) 0.14 0.890
Japan 3 1369/1933 0.97 (0.91, 1.03) 1.03 0.301
Caucasian 18 6868/15,610 0.99 (0.96, 1.02) 0.86 0.391
Asian 5 1453/2121 0.95(0.90, 1.01) 1.53 0.126
hyperplastic polyps 2 213/702 0.99 (0.84, 1.16) 0.13 0.897
adenomatous polyps 20 8086/16,994 0.98 (0.95, 1.01) 1.43 0.153
TT vs. CC overall 22 8317/17,696 0.97 (0.90, 1.05) 0.75 0.454
UK 6 1353/1517 1.05 (0.85, 1.30) 0.47 0.641
USA 7 2841/4308 1.01 (0.89, 1.14) 0.11 0.913
Japan 3 1369/1933 0.95 (0.82, 1.11) 0.61 0.540
Caucasian 17 6846/15,575 0.99 (0.91, 1.08) 0.31 0.760
Asian 5 1453/2121 0.92(0.80, 1.07) 1.06 0.291
hyperplastic polyps 2 213/702 1.13 (0.77, 1.65) 0.62 0.532
adenomatous polyps 20 8086/16,994 0.97(0.77, 1.65) 0.88 0.377
CT vs. CC overall 23 8321/17,731 0.97 (0.94, 1.00) 1.77 0.077
UK 6 1353/1517 0.96 (0.89, 1.04) 0.93 0.351
USA 8 2863/4343 0.99 (0.94, 1.04) 0.44 0.663
Japan 3 1369/1933 0.94 (0.88, 1.01) 1.67 0.094
Caucasian 18 6868/15,610 0.98 (0.95, 1.01) 1.11 0.269
Asian 5 1453/2121 0.94 (0.87, 1.00) 1.92 0.055
hyperplastic polyps 2 213/702 0.88 (0.73, 1.07) 1.27 0.205
adenomatous polyps 20 8086/16,994 0.98 (0.95, 1.01) 1.58 0.113
CT + TT vs. CC overall 23 8321/17,731 0.98 (0.95, 1.00) 1.76 0.079
UK 6 1353/1517 0.98 (0.91, 1.06) 0.66 0.511
USA 8 2863/4343 0.99 (0.95, 1.04) 0.33 0.743
Japan 3 1369/1933 0.96 (0.91, 1.01) 1.53 0.125
Caucasian 18 6868/15,610 0.98 (0.96, 1.01) 1.08 0.280
Asian 5 1453/2121 0.95 (0.90, 1.00) 1.95 0.052
hyperplastic polyps 2 213/702 0.94 (0.80, 1.09) 0.82 0.414
adenomatous polyps 20 8086/16,994 0.98 (0.95, 1.00) 1.65 0.098
TT vs. CC + CT overall 22 8317/17,696 0.99 (0.92, 1.07) 0.19 0.847
UK 6 1353/1517 1.09 (0.87, 1.36) 078 0.436
USA 7 2841/4308 1.02 (0.89, 1.16) 0.23 0.822
Japan 3 1369/1933 1.01 (0.86, 1.18) 0.08 0.934
Caucasian 17 6846/15,575 1.00 (0.91, 1.09) 0.07 0.944
Asian 5 1453/2121 0.98 (0.83, 1.15) 0.28 0.780
hyperplastic polyps 2 213/702 1.23 (0.83, 1.84) 1.04 0.299
adenomatous polyps 20 8086/16,994 0.98(0.91, 1.84) 0.39 0.696
carrier T vs. carrier C overall 23 8321/17,731 0.99 (0.96, 1.01) 0.99 0.322
UK 6 1353/1517 0.99 (0.92, 1.07) 0.21 0.831
USA 8 2863/4343 1.00 (0.95, 1.05) 0.15 0.883
Japan 3 1369/1933 0.98 (0.91, 1.05) 0.69 0.491
Caucasian 18 6868/15,610 0.99 (0.96, 1.02) 0.64 0.523
Asian 5 1453/2121 0.97 (0.90, 1.03) 0.99 0.322
hyperplastic polyps 2 213/702 0.98 (0.82, 1.16) 0.26 0.793
adenomatous polyps 20 8086/16,994 0.99(0.96, 1.02) 0.97 0.331
  1. RRs Risk ratios, CIs Confidence intervals