Table 2 Pooled analysis for the MTHFR rs1801133 polymorphism
Comparison | Subgroup | Sample size | Test of association | |||
|---|---|---|---|---|---|---|
Studies | Case/control | RRs (95% CIs) | z | P | ||
allele T vs. allele C | overall | 23 | 8321/17,731 | 0.98 (0.95, 1.01) | 1.42 | 0.156 |
UK | 6 | 1353/1517 | 0.99 (0.92, 1.07) | 0.14 | 0.886 | |
USA | 8 | 2863/4343 | 1.00 (0.95, 1.05) | 0.14 | 0.890 | |
Japan | 3 | 1369/1933 | 0.97 (0.91, 1.03) | 1.03 | 0.301 | |
Caucasian | 18 | 6868/15,610 | 0.99 (0.96, 1.02) | 0.86 | 0.391 | |
Asian | 5 | 1453/2121 | 0.95(0.90, 1.01) | 1.53 | 0.126 | |
hyperplastic polyps | 2 | 213/702 | 0.99 (0.84, 1.16) | 0.13 | 0.897 | |
adenomatous polyps | 20 | 8086/16,994 | 0.98 (0.95, 1.01) | 1.43 | 0.153 | |
TT vs. CC | overall | 22 | 8317/17,696 | 0.97 (0.90, 1.05) | 0.75 | 0.454 |
UK | 6 | 1353/1517 | 1.05 (0.85, 1.30) | 0.47 | 0.641 | |
USA | 7 | 2841/4308 | 1.01 (0.89, 1.14) | 0.11 | 0.913 | |
Japan | 3 | 1369/1933 | 0.95 (0.82, 1.11) | 0.61 | 0.540 | |
Caucasian | 17 | 6846/15,575 | 0.99 (0.91, 1.08) | 0.31 | 0.760 | |
Asian | 5 | 1453/2121 | 0.92(0.80, 1.07) | 1.06 | 0.291 | |
hyperplastic polyps | 2 | 213/702 | 1.13 (0.77, 1.65) | 0.62 | 0.532 | |
adenomatous polyps | 20 | 8086/16,994 | 0.97(0.77, 1.65) | 0.88 | 0.377 | |
CT vs. CC | overall | 23 | 8321/17,731 | 0.97 (0.94, 1.00) | 1.77 | 0.077 |
UK | 6 | 1353/1517 | 0.96 (0.89, 1.04) | 0.93 | 0.351 | |
USA | 8 | 2863/4343 | 0.99 (0.94, 1.04) | 0.44 | 0.663 | |
Japan | 3 | 1369/1933 | 0.94 (0.88, 1.01) | 1.67 | 0.094 | |
Caucasian | 18 | 6868/15,610 | 0.98 (0.95, 1.01) | 1.11 | 0.269 | |
Asian | 5 | 1453/2121 | 0.94 (0.87, 1.00) | 1.92 | 0.055 | |
hyperplastic polyps | 2 | 213/702 | 0.88 (0.73, 1.07) | 1.27 | 0.205 | |
adenomatous polyps | 20 | 8086/16,994 | 0.98 (0.95, 1.01) | 1.58 | 0.113 | |
CT + TT vs. CC | overall | 23 | 8321/17,731 | 0.98 (0.95, 1.00) | 1.76 | 0.079 |
UK | 6 | 1353/1517 | 0.98 (0.91, 1.06) | 0.66 | 0.511 | |
USA | 8 | 2863/4343 | 0.99 (0.95, 1.04) | 0.33 | 0.743 | |
Japan | 3 | 1369/1933 | 0.96 (0.91, 1.01) | 1.53 | 0.125 | |
Caucasian | 18 | 6868/15,610 | 0.98 (0.96, 1.01) | 1.08 | 0.280 | |
Asian | 5 | 1453/2121 | 0.95 (0.90, 1.00) | 1.95 | 0.052 | |
hyperplastic polyps | 2 | 213/702 | 0.94 (0.80, 1.09) | 0.82 | 0.414 | |
adenomatous polyps | 20 | 8086/16,994 | 0.98 (0.95, 1.00) | 1.65 | 0.098 | |
TT vs. CC + CT | overall | 22 | 8317/17,696 | 0.99 (0.92, 1.07) | 0.19 | 0.847 |
UK | 6 | 1353/1517 | 1.09 (0.87, 1.36) | 078 | 0.436 | |
USA | 7 | 2841/4308 | 1.02 (0.89, 1.16) | 0.23 | 0.822 | |
Japan | 3 | 1369/1933 | 1.01 (0.86, 1.18) | 0.08 | 0.934 | |
Caucasian | 17 | 6846/15,575 | 1.00 (0.91, 1.09) | 0.07 | 0.944 | |
Asian | 5 | 1453/2121 | 0.98 (0.83, 1.15) | 0.28 | 0.780 | |
hyperplastic polyps | 2 | 213/702 | 1.23 (0.83, 1.84) | 1.04 | 0.299 | |
adenomatous polyps | 20 | 8086/16,994 | 0.98(0.91, 1.84) | 0.39 | 0.696 | |
carrier T vs. carrier C | overall | 23 | 8321/17,731 | 0.99 (0.96, 1.01) | 0.99 | 0.322 |
UK | 6 | 1353/1517 | 0.99 (0.92, 1.07) | 0.21 | 0.831 | |
USA | 8 | 2863/4343 | 1.00 (0.95, 1.05) | 0.15 | 0.883 | |
Japan | 3 | 1369/1933 | 0.98 (0.91, 1.05) | 0.69 | 0.491 | |
Caucasian | 18 | 6868/15,610 | 0.99 (0.96, 1.02) | 0.64 | 0.523 | |
Asian | 5 | 1453/2121 | 0.97 (0.90, 1.03) | 0.99 | 0.322 | |
hyperplastic polyps | 2 | 213/702 | 0.98 (0.82, 1.16) | 0.26 | 0.793 | |
adenomatous polyps | 20 | 8086/16,994 | 0.99(0.96, 1.02) | 0.97 | 0.331 | |