The VDR gene FokI polymorphism is associated with gestational diabetes mellitus in Turkish women

BMC Medical Genetics

Table 3 Genotype analysis of VDR gene SNPs

	Non-GDM (n = 134)	GDM (n = 100)	OR (95% CI)	P
ApaI rs7975232 (%)
Co-dominant Wild type AA	19.4	17.0
Heterozygous AC	56.7	52.0	1.04 (0.51–2.12)	0.985
Homozygous CC	23.9	31.0	1.48 (0.67–3.25)	0.326
Dominant (AA/AC + CC)			1.17 (0.59–2.30)	0.639
Recessive (AA+AC/CC)			1.43 (0.80–2.56)	0.225
TaqI rs731236 (%)
Co-dominant Wild type TT	40.0	44.0
Heterozygous CT	49.6	42.0	0.76 (0.44–1.33)	0.353
Homozygous CC	10.4	14.0	1.22 (0.52–2.84)	0.633
Dominant (TT/CT + CC)			0.84 (0.50–1.43)	0.539
Recessive (TT + CT/CC)			1.40 (0.63–3.10)	0.396
BsmI rs1544410 (%)
Co-dominant Wild type AA	31.9	42.0
Heterozygous AG	57.0	44.0	0.58 (0.33–1.02)	0.062
Homozygous GG	11.1	14.0	0.95 (0.41–2.22)	0.916
Dominant (AA/AG + GG)			0.64 (0.37–1.10)	0.109
Recessive (AA+AG/GG)			1.30 (0.59–2.83)	0.506
FokI rs2228570 (%)
Co-dominant Wild type CC	60.0	41.0
Heterozygous CT	34.1	43.0	1.84 (1.05–3.23)	0.031
Homozygous TT	5.9	16.0	3.95 (1.56–9.96)	0.002
Dominant (CC/CT + TT)			2.29 (1.35–3.89)	0.002
Recessive (CC + CT/TT)			3.02 (1.23–7.38)	0.012

GDM gestational diabetes mellitus
SNPs were expressed as allelic frequency (q) or prevalence of genotypes (%)
Categorical variables were analyzed with Chi-square test or Fisher’s exact test, where appropriate
Multiple logistic regression analysis and Fisher’s exact test were tested using models: dominant (major allele homozygotes vs heterozygotes + minor allele homozygotes), recessive (major allele homozygotes + heterozygotes vs minor allele homozygotes) and codominant (major allele homozygotes vs heterozygote and minor allele homozygotes vs major allele homozygotes)
Bold represents significant p-values

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