Table 4 Meta-analysis of IL-10 -592 A/C SNP
From: Genetic relationship between IL-10 gene polymorphisms and the risk of clinical atopic dermatitis
Genetic model | Group | Study number | Case/Control | P | OR (95% CI) |
|---|---|---|---|---|---|
Allele C vs. A | Overall | 9 | 1032/1363 | 0.109 | 0.85 (0.70~1.04) |
Asian | 6 | 774/844 | 0.033 | 0.85 (0.73~0.99) | |
Caucasian | 3 | 258/519 | 0.788 | 0.92 (0.49~1.73) | |
Y | 8 | 994/1325 | 0.204 | 0.88 (0.73~1.07) | |
Asian/Y | 5 | 736/806 | 0.086 | 0.87 (0.74~1.02) | |
Caucasian/Y | 3 | 258/519 | 0.788 | 0.92 (0.49~1.73) | |
CC vs. AA | Overall | 8 | 938/1177 | 0.227 | 0.72 (0.42~1.23) |
Asian | 5 | 680/658 | 0.353 | 0.75 (0.40~1.38) | |
Caucasian | 3 | 258/519 | 0.582 | 0.71 (0.21~2.38) | |
Y | 7 | 900/1139 | 0.349 | 0.80 (0.50~1.28) | |
Asian/Y | 4 | 642/620 | 0.471 | 0.86 (0.56~1.30) | |
Caucasian/Y | 3 | 258/519 | 0.582 | 0.71 (0.21~2.38) | |
AC vs. AA | Overall | 8 | 938/1177 | 0.039 | 0.77 (0.59~0.99) |
Asian | 5 | 680/658 | 0.061 | 0.77 (0.58~1.01) | |
Caucasian | 3 | 258/519 | 0.387 | 0.76 (0.41~1.41) | |
Y | 7 | 900/1139 | 0.093 | 0.80 (0.62~1.04) | |
Asian/Y | 4 | 642/620 | 0.146 | 0.81 (0.61~1.08) | |
Caucasian/Y | 3 | 258/519 | 0.387 | 0.76 (0.41~1.41) | |
AC + CC vs. AA | Overall | 8 | 938/1177 | 0.026 | 0.76 (0.60~0.97) |
Asian | 5 | 680/658 | 0.049 | 0.77 (0.59~1.00) | |
Caucasian | 3 | 258/519 | 0.290 | 0.73 (0.41~1.31) | |
Y | 7 | 900/1139 | 0.069 | 0.80 (0.62~1.02) | |
Asian/Y | 4 | 642/620 | 0.128 | 0.81 (0.62~1.06) | |
Caucasian/Y | 3 | 258/519 | 0.290 | 0.73 (0.41~1.31) | |
CC vs. AA + AC | Overall | 8 | 938/1177 | 0.416 | 0.86 (0.61~1.23) |
Asian | 5 | 680/658 | 0.194 | 0.83 (0.62~1.10) | |
Caucasian | 3 | 258/519 | 0.892 | 0.94 (0.41~2.19) | |
Y | 7 | 900/1139 | 0.597 | 0.91 (0.63~1.30) | |
Asian/Y | 4 | 642/620 | 0.324 | 0.86 (0.64~1.16) | |
Caucasian/Y | 3 | 258/519 | 0.892 | 0.94 (0.41~2.19) | |
Carrier C vs. A | Overall | 8 | 938/1177 | 0.170 | 0.90 (0.77~1.05) |
Asian | 5 | 680/658 | 0.180 | 0.88 (0.73~1.06) | |
Caucasian | 3 | 258/519 | 0.640 | 0.94 (0.71~1.24) | |
Y | 7 | 900/1139 | 0.244 | 0.91 (0.77~1.07) | |
Asian/Y | 4 | 642/620 | 0.273 | 0.90 (0.74~1.09) | |
Caucasian/Y | 3 | 258/519 | 0.640 | 0.94 (0.71~1.24) |