Table 3 Meta-analysis of IL-10 -819 T/C SNP
From: Genetic relationship between IL-10 gene polymorphisms and the risk of clinical atopic dermatitis
Genetic model | Group | Study number | Case/Control | P | OR (95% CI) |
|---|---|---|---|---|---|
Allele C vs. T | Overall | 9 | 1228/1544 | 0.547 | 0.93 (0.74~1.18) |
Asian | 7 | 1074/1143 | 0.550 | 0.92 (0.71~1.20) | |
China | 3 | 567/614 | 0.893 | 1.03 (0.63~1.70) | |
Y | 7 | 1102/1404 | 0.610 | 0.94 (0.73~1.21) | |
Asian/Y | 6 | 1036/1105 | 0.866 | 0.98 (0.75~1.28) | |
CC vs. TT | Overall | 8 | 1134/1358 | 0.588 | 0.83 (0.42~1.63) |
Asian | 6 | 980/957 | 0.915 | 0.96 (0.46~1.99) | |
Y | 6 | 1008/1218 | 0.870 | 1.06 (0.54~2.07) | |
Asian/Y | 5 | 942/919 | 0.593 | 1.19 (0.63~2.26) | |
TC vs. TT | Overall | 8 | 1134/1358 | 0.405 | 0.83 (0.55~1.28) |
Asian | 6 | 980/957 | 0.697 | 0.90 (0.54~1.51) | |
Y | 6 | 1008/1218 | 0.892 | 0.97 (0.65~1.45) | |
Asian/Y | 5 | 942/919 | 0.995 | 1.00 (0.62~1.62) | |
TC + CC vs. TT | Overall | 8 | 1134/1358 | 0.433 | 0.84 (0.55~1.30) |
Asian | 6 | 980/957 | 0.693 | 0.90 (0.53~1.52) | |
Y | 6 | 1008/1218 | 0.845 | 0.96 (0.63~1.47) | |
Asian/Y | 5 | 942/919 | 0.975 | 1.01 (0.61~1.66) | |
CC vs. TT + TC | Overall | 8 | 1134/1358 | 0.821 | 1.05 (0.69~1.60) |
Asian | 6 | 980/957 | 0.991 | 1.00 (0.64~1.55) | |
Y | 6 | 1008/1218 | 0.900 | 1.03 (0.65~1.64) | |
Asian/Y | 5 | 942/919 | 0.706 | 1.09 (0.70~1.70) | |
Carrier C vs. T | Overall | 8 | 1134/1358 | 0.801 | 1.02 (0.88~1.17) |
Asian | 6 | 980/957 | 0.816 | 1.02 (0.87~1.19) | |
Y | 6 | 1008/1218 | 0.867 | 1.01 (0.87~1.18) | |
Asian/Y | 5 | 942/919 | 0.631 | 1.04 (0.89~1.22) |