Table 2 Meta-analysis of IL-10 -1082 A/G SNP
From: Genetic relationship between IL-10 gene polymorphisms and the risk of clinical atopic dermatitis
Genetic model | Group | Study number | Case/Control | P | OR (95% CI) |
|---|---|---|---|---|---|
Allele G vs. A | Overall | 14 | 1593/2095 | 0.540 | 0.96 (0.86~1.07) |
Asian | 6 | 774/844 | 0.990 | 1.00 (0.82~1.22) | |
Caucasian | 7 | 751/1201 | 0.395 | 0.94 (0.83~1.08) | |
Poland | 3 | 402/468 | 0.562 | 0.95 (0.78~1.14) | |
Y | 9 | 1208/1305 | 0.326 | 0.93 (0.82~1.07) | |
Asian/Y | 3 | 543/455 | 0.751 | 1.06 (0.74~1.51) | |
Caucasian/Y | 5 | 597/800 | 0.238 | 0.91 (0.78~1.06) | |
Poland/Y | 3 | 402/468 | 0.562 | 0.95 (0.78~1.14) | |
GG vs. AA | Overall | 11 | 1288/1742 | 0.853 | 0.98 (0.76~1.25) |
Asian | 3 | 469/491 | 0.144 | 1.55 (0.86~2.78) | |
Caucasian | 7 | 751/1201 | 0.390 | 0.88 (0.66~1.17) | |
Poland | 3 | 402/468 | 0.513 | 0.88 (0.61~1.28) | |
Y | 7 | 941/990 | 0.241 | 0.84 (0.63~1.12) | |
Caucasian/Y | 5 | 597/800 | 0.299 | 0.85 (0.63~1.15) | |
Poland/Y | 3 | 402/468 | 0.513 | 0.88 (0.61~1.28) | |
AG vs AA | Overall | 13 | 1499/1909 | 0.265 | 0.84 (0.62~1.14) |
Asian | 5 | 680/658 | 0.216 | 0.66 (0.35~1.27) | |
Caucasian | 7 | 751/1201 | 0.720 | 0.93 (0.65~1.35) | |
Poland | 3 | 402/468 | 0.753 | 1.05 (0.77~1.43) | |
Y | 8 | 1114/1119 | 0.975 | 1.00 (0.81~1.23) | |
Caucasian/Y | 5 | 597/800 | 0.683 | 0.94 (0.71~1.26) | |
Poland/Y | 3 | 402/468 | 0.753 | 1.05 (0.77~1.43) | |
AG + GG vs AA | Overall | 14 | 1536/2041 | 0.221 | 0.85 (0.65~1.10) |
Asian | 5 | 680/658 | 0.268 | 0.71 (0.39~1.30) | |
Caucasian | 8 | 788/1333 | 0.502 | 0.90 (0.66~1.23) | |
Poland | 3 | 402/468 | 0.957 | 0.99 (0.75~1.32) | |
Y | 9 | 1151/1251 | 0.521 | 0.94 (0.77~1.14) | |
Caucasian/Y | 6 | 634/932 | 0.369 | 0.88 (0.68~1.16) | |
Poland/Y | 3 | 402/468 | 0.957 | 0.99 (0.75~1.32) | |
GG vs AA + AG | Overall | 11 | 1288/1742 | 0.540 | 1.07 (0.86~1.32) |
Asian | 3 | 469/491 | 0.003 | 2.22 (1.32~3.74) | |
Caucasian | 7 | 751/1201 | 0.538 | 0.93 (0.72~1.18) | |
Poland | 3 | 402/468 | 0.358 | 0.86 (0.62~1.19) | |
Y | 7 | 941/990 | 0.233 | 0.86 (0.67~1.10) | |
Caucasian/Y | 5 | 597/800 | 0.295 | 0.87 (0.67~1.13) | |
Poland/Y | 3 | 402/468 | 0.358 | 0.86 (0.62~1.19) | |
Carrier G vs. A | Overall | 13 | 1499/1909 | 0.643 | 0.97 (0.86~1.10) |
Asian | 5 | 680/658 | 0.968 | 1.00 (0.79~1.25) | |
Caucasian | 7 | 751/1201 | 0.608 | 0.96 (0.82~1.12) | |
Poland | 3 | 402/468 | 0.751 | 0.96 (0.77~1.21) | |
Y | 8 | 1114/1119 | 0.619 | 0.96 (0.82~1.13) | |
Caucasian/Y | 5 | 597/800 | 0.475 | 0.94 (0.78~1.12) | |
Poland/Y | 3 | 402/468 | 0.751 | 0.96 (0.77~1.21) |