Potential |  | Odd Ratio (CI 95%) | No of Studies | Heterogeneity χ2 | P value | I2 | Interaction p value |
---|---|---|---|---|---|---|---|
A Homozygote model: MM vs. TT | |||||||
Ethnicity | Caucasian | 0.922 (0.838–1.016) | 31 | 63.02 | 0.000 | 52.4% | 0.0001 |
Asian | 0.725 (0.345–1.522) | 8 | 18.89 | 0.009 | 62.9% | ||
African-American | 1.278 (0.826–1.977) | 2 | 0.77 | 0.381 | 0.0% | ||
Arab | 3.649 (2.029–6.563) | 2 | 0.26 | 0.609 | 0.0% | ||
Mixed | 0.889 (0.694–1.140) | 10 | 16.49 | 0.009 | 45.4% | ||
Study-based | Hospital-based | 0.979 (0.825–1.162) | 36 | 81.66 | 0.000 | 57.1% | 0.655 |
Population-based | 0.869 (0.796–0.950) | 17 | 26.22 | 0.051 | 39.0% | ||
Methodological quality | Good | 0.974 (0.786–1.208) | 15 | 36.70 | 0.001 | 61.9% | 0.891 |
Fair | 0.930 (0.830–1.041) | 36 | 84.07 | 0.000 | 58.4% | ||
Poor | 0.644 (0.338–1.229) | 2 | 0.37 | 0.544 | 0.0% | ||
Case enrollment strategies | Incident | 0.938 (0.819–1.075) | 20 | 54.88 | 0.000 | 59.9% | 0.455 |
Prevalent | 0.887 (0.720–1.093) | 23 | 45.70 | 0.001 | 58.4% | ||
Not mentioned | 0.975 (0.798–1.191) | 10 | 21.53 | 0.011 | 58.2% | ||
All studies |  | 0.937 (0.849–1.034) | 53 | 124.20 | 0.000 | 58.1% | – |
B Dominant model: TM + MM vs. TT | |||||||
Ethnicity | Caucasian | 1.022 (0.969–1.079) | 31 | 43.65 | 0.051 | 31.3% | 0.0001 |
Asian | 1.296 (1.027–1.636) | 8 | 18.22 | 0.011 | 61.6% | ||
African-American | 0.921 (0.749–1.134) | 2 | 0.53 | 0.465 | 0.0% |  | |
Arab | 0.671 (0.419–1.074) | 2 | 0.00 | 0.950 | 0.0% | ||
Mixed | 1.084 (0.863–1.361) | 10 | 33.91 | 0.000 | 73.5% | ||
Study-based | Hospital-based | 1.089 (0.975–1.215) | 36 | 89.81 | 0.000 | 61.0% | 0.655 |
Population-based | 1.017 (0.955–1.084) | 17 | 31.38 | 0.012 | 49.0% | ||
Methodological quality | Good | 1.028 (0.950–1.112) | 15 | 36.88 | 0.001 | 62.0% | 0.891 |
Fair | 1.050 (1.010–1.091) | 36 | 84.16 | 0.000 | 58.4% | ||
Poor | 1.022 (0.643–1.624) | 2 | 0.12 | 0.725 | 0.0% | ||
Case enrollment strategies | Incident | 1.011 (0.934–1.095) | 20 | 37.53 | 0.007 | 49.4% | 0.455 |
Prevalent | 1.111 (0.958–1.289) | 23 | 74.40 | 0.000 | 70.4% | ||
Not mentioned | 1.042 (0.975–1.113) | 10 | 7.89 | 0.545 | 0.0% | ||
All studies |  | 1.045 (0.982–1.112) | 53 | 121.39 | 0.000 | 57.2% | – |
C Recessive model: MM vs. TM + TT | |||||||
Ethnicity | Caucasian | 0.921 (0.849–1.000) | 31 | 56.42 | 0.002 | 46.8% | 0.000 |
Asian | 0.688 (0.374–1.266) | 8 | 15.51 | 0.030 | 54.9% | ||
African-American | 1.265 (0.778–2.055) | 2 | 1.02 | 0.312 | 2.2% | ||
Arab | 3.649 (2.029–6.563) | 2 | 1.55 | 0.213 | 35.4% | ||
Mixed | 0.895 (0.728–1.101) | 10 | 13.93 | 0.125 | 35.4% | ||
Study-based | Hospital-based | 0.989 (0.844–1.159) | 36 | 90.43 | 0.000 | 61.3% | 0.00 |
Population-based | 0.868 (0.806–0.934) | 17 | 21.79 | 0.150 | 26.6% | ||
Methodological quality | Good | 0.961 (0.822–1.125) | 15 | 27.19 | 0.018 | 48.5% | 0.153 |
Fair | 0.942 (0.841–1.055) | 36 | 99.37 | 0.000 | 64.8% | ||
Poor | 0.645 (0.355–1.173) | 2 | 0.84 | 0.359 | 0.0% | ||
Case enrollment strategies | Incident | 0.950 (0.823–1.097) | 20 | 63.03 | 0.000 | 69.9% | 0.377 |
Prevalent | 0.900 (0.761–1.064) | 23 | 45.19 | 0.003 | 51.3% | ||
Not mentioned | 0.974 (0.812–1.168) | 10 | 21 | 0.013 | 57.1% | ||
All studies |  | 0.939 (0.857–1.029) | 55 | 131.15 | 0.000 | 60.3% | – |