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Table 3 Meta-analysis of studies reporting sporadic cases in different subgroups

From: Associations between XRCC3 Thr241Met polymorphisms and breast cancer risk: systematic-review and meta-analysis of 55 case-control studies

Potential

 

Odd Ratio

(CI 95%)

No of Studies

Heterogeneity χ2

P value

I2

Interaction p value

A Homozygote model: MM vs. TT

Ethnicity

Caucasian

0.922 (0.838–1.016)

31

63.02

0.000

52.4%

0.0001

Asian

0.725 (0.345–1.522)

8

18.89

0.009

62.9%

African-American

1.278 (0.826–1.977)

2

0.77

0.381

0.0%

Arab

3.649 (2.029–6.563)

2

0.26

0.609

0.0%

Mixed

0.889 (0.694–1.140)

10

16.49

0.009

45.4%

Study-based

Hospital-based

0.979 (0.825–1.162)

36

81.66

0.000

57.1%

0.655

Population-based

0.869 (0.796–0.950)

17

26.22

0.051

39.0%

Methodological quality

Good

0.974 (0.786–1.208)

15

36.70

0.001

61.9%

0.891

Fair

0.930 (0.830–1.041)

36

84.07

0.000

58.4%

Poor

0.644 (0.338–1.229)

2

0.37

0.544

0.0%

Case enrollment strategies

Incident

0.938 (0.819–1.075)

20

54.88

0.000

59.9%

0.455

Prevalent

0.887 (0.720–1.093)

23

45.70

0.001

58.4%

Not mentioned

0.975 (0.798–1.191)

10

21.53

0.011

58.2%

All studies

 

0.937 (0.849–1.034)

53

124.20

0.000

58.1%

–

B Dominant model: TM + MM vs. TT

Ethnicity

Caucasian

1.022 (0.969–1.079)

31

43.65

0.051

31.3%

0.0001

Asian

1.296 (1.027–1.636)

8

18.22

0.011

61.6%

African-American

0.921 (0.749–1.134)

2

0.53

0.465

0.0%

 

Arab

0.671 (0.419–1.074)

2

0.00

0.950

0.0%

Mixed

1.084 (0.863–1.361)

10

33.91

0.000

73.5%

Study-based

Hospital-based

1.089 (0.975–1.215)

36

89.81

0.000

61.0%

0.655

Population-based

1.017 (0.955–1.084)

17

31.38

0.012

49.0%

Methodological quality

Good

1.028 (0.950–1.112)

15

36.88

0.001

62.0%

0.891

Fair

1.050 (1.010–1.091)

36

84.16

0.000

58.4%

Poor

1.022 (0.643–1.624)

2

0.12

0.725

0.0%

Case enrollment strategies

Incident

1.011 (0.934–1.095)

20

37.53

0.007

49.4%

0.455

Prevalent

1.111 (0.958–1.289)

23

74.40

0.000

70.4%

Not mentioned

1.042 (0.975–1.113)

10

7.89

0.545

0.0%

All studies

 

1.045 (0.982–1.112)

53

121.39

0.000

57.2%

–

C Recessive model: MM vs. TM + TT

Ethnicity

Caucasian

0.921 (0.849–1.000)

31

56.42

0.002

46.8%

0.000

Asian

0.688 (0.374–1.266)

8

15.51

0.030

54.9%

African-American

1.265 (0.778–2.055)

2

1.02

0.312

2.2%

Arab

3.649 (2.029–6.563)

2

1.55

0.213

35.4%

Mixed

0.895 (0.728–1.101)

10

13.93

0.125

35.4%

Study-based

Hospital-based

0.989 (0.844–1.159)

36

90.43

0.000

61.3%

0.00

Population-based

0.868 (0.806–0.934)

17

21.79

0.150

26.6%

Methodological quality

Good

0.961 (0.822–1.125)

15

27.19

0.018

48.5%

0.153

Fair

0.942 (0.841–1.055)

36

99.37

0.000

64.8%

Poor

0.645 (0.355–1.173)

2

0.84

0.359

0.0%

Case enrollment strategies

Incident

0.950 (0.823–1.097)

20

63.03

0.000

69.9%

0.377

Prevalent

0.900 (0.761–1.064)

23

45.19

0.003

51.3%

Not mentioned

0.974 (0.812–1.168)

10

21

0.013

57.1%

All studies

 

0.939 (0.857–1.029)

55

131.15

0.000

60.3%

–