Associations between XRCC3 Thr241Met polymorphisms and breast cancer risk: systematic-review and meta-analysis of 55 case-control studies

Dashti, Sepideh; Taherian-Esfahani, Zahra; Keshtkar, Abbasali; Ghafouri-Fard, Soudeh

doi:10.1186/s12881-019-0809-8

Table 2 General characteristics of studies reporting associations in sporadic breast cancer (HB: hospital based, PB: population based, HWE: Hardy-Weinberg Equilibrium, NOS: The Newcastle-Ottawa Scale)

From: Associations between XRCC3 Thr241Met polymorphisms and breast cancer risk: systematic-review and meta-analysis of 55 case-control studies

First Author	Year	Society	Country	Ethnicity	Genotyping Method	Case-enrollment strategy	Frequency in Cases				Frequency in Controls				HWE	NOS Score
First Author	Year	Society	Country	Ethnicity	Genotyping Method	Case-enrollment strategy	TT	TM	MM	Total	TT	TM	MM	Total	HWE	NOS Score
Al Zoubi	2015	HB	Jordan	Arab	Sequencing	Prevalent	16	26	4	46	8	18	5	31	0.33	5
Al Zoubi	2017	HB	Italy	Caucasian	Sequencing	Prevalent	8	13	2	23	4	9	2	15	0.72	5
Ali	2016	HB	Saudi Arabian	Arab	PCR-RFLP	Incident	43	73	27	143	32	32	78	35	> 0.05	6
Brooks	2008	PB	USA	Mixed	PCR-RFLP	Incident	254	259	98	611	249	286	76	611	0.661	9
Costa	2007	HB	Portugal	Caucasian	PCR-RFLP	Prevalent	68	77	31	176	121	61	29	211	0	5
Devi	2017	HB	India	Asian	PCR-RFLP	Prevalent	350	100	14	464	426	99	9	534	0.25	10
Ding	2015	HB	China	Asian	PCR-LDR	Prevalent	510	91	5	606	557	74	2	633	0.25	7
Dufloth	2005	HB	Brazil	Mixed	PCR-RFLP	Prevalent	15	16	2	33	68	35	15	118	0.005	3
Figueiredo	2004	PB	Canada	Caucasian	MALDI-TOF MS	incident	110	148	61	319	133	180	52	365	0.39	9
Forsti	2004	PB	Finland	Caucasian	PCR-RFLP	Prevalent	111	80	32	223	161	110	27	298	0.654	4
Garcia-Closas	2006	PB	Poland	Caucasian	NA	Incident	785	907	282	1974	980	1039	266	2285	0.709	7
Garcia-Closas	2006	PB	USA	Caucasian	NA	Incident	1102	1419	457	2978	973	1213	368	2554	0.748	7
Gohari-Lasaki	2015	HB	Iran	Mixed	PCR-RFLP	Prevalent	70	13	17	100	69	22	9	100	NA	2
Han	2004	PB	USA	Mixed	Taq-Man	Incident	388	429	135	952	468	607	170	1245	0.225	8
Jacobsen	2003	PB	Denmark	Caucasian	Taq-Man / PCR-RFLP	Incident	163	203	59	425	160	198	65	423	0.772	4
Kipen	2017	HB	Belarus	Caucasian	PCR-RFLP	Incident	86	68	15	169	84	94	7	185	> 0.05	5
Krupa	2009	HB	Poland	Caucasian	PCR-RFLP	Prevalent	29	68	38	135	29	107	39	175	0.003	4
Kuschel	2002	PB	UK	Caucasian	Taq-Man	Incident	790	1026	327	2143	728	827	229	1784	0.8	4
Lavanya	2015	HB	India	Asian	PCR-RFLP	N/M	42	7	1	50	40	8	2	50	> 0.05	6
Lee	2007	HB	South Korea	Asian	Single base extension assay	Prevalent	437	51	1	489	349	29	0	378	0.74	6
Loizidou	2008	PB	Cyprus	Mixed	PCR-RFLP	Incident	312	560	220	1092	351	600	226	1177	0.285	8
Millikan	2005	PB	USA	Caucasian	Taq-Man	Incident	505	578	171	1254	435	555	142	1132	0.086	9
Millikan	2005	PB	USA	African-American	Taq-Man	Incident	482	222	41	745	421	211	44	676	0.015	9
Ozgoz	2017	HB	Turkey	Mixed	Multiplex-PCR & MALDI-TOF	Prevalent	42	46	14	102	37	40	23	100	0.234	7
Qureshi	2014	HB	Pakistan	Mixed	PCR-RFLP	Prevalent	74	67	15	156	101	44	5	105	> 0.05	6
Rafii	2003	HB	UK	Caucasian	Taq-Man	Prevalent	201	248	72	521	341	416	129	886	0.87	8
Ramadan	2014	HB	Egypt	Mixed	PCR-RFLP	Incident	28	57	15	100	30	37	8	75	0.491	7
Romanowicz	2017	HB	Poland	Caucasian	HRM	Prevalent	48	72	80	200	52	72	76	200	0.862	6
Romanowicz-Makowska	2012	HB	Poland	Caucasian	PCR-RFLP	Prevalent	210	370	180	760	178	366	216	760	0.343	5
Romanowicz-Makowska	2011	HB	Poland	Caucasian	PCR-RFLP	Prevalent	220	378	192	790	188	384	226	798	0.939	5
Sangrajrang	2007	HB	Thai	Asian	Melting curve analysis	Incident	437	69	1	507	384	38	2	424	0.322	6
Santos	2010	HB	Brazil	Mixed	PCR-RFLP	Incident	28	31	6	65	49	29	7	85	0.37	6
Shadrina	2016	PB	Russia	Caucasian	Taq-Man	Prevalent	285	284	95	664	294	278	72	644	0.59	6
Silva	2010	HB	Portugal	Caucasian	PCR-RFLP	N/M	109	138	42	289	178	276	94	548	0.46	6
Smith	2008	HB	USA	Caucasian	Mass ARRAY system	Incident	124	137	54	315	158	184	59	401	0.649	5
Smith	2008	HB	USA	African-American	Mass ARRAY system	Incident	32	19	1	52	48	20	5	73	0.169	7
Smith a	2003	HB	USA	Caucasian	PCR-RFLP	Incident	96	105	51	252	104	129	35	268	0.611	7
Smith b	2003	PB	USA	Caucasian	PCR-RFLP	Incident	30	40	17	87	39	55	15	109	0.68	7
Smolarz	2015	HB	Poland	Caucasian	PCR-RFLP	Prevalent	19	35	16	70	15	35	20	70	0.718	6
Sobczuk	2009	HB	Poland	Caucasian	PCR-RFLP	Prevalent	29	71	50	150	24	50	32	106	0.567	5
Sterpone	2010	HB	Italy	Caucasian	PCR-RFLP	Prevalent	18	21	4	43	15	15	4	34	0.853	6
Su	2015	HB	Taiwan	Asian	PCR-RFLP	Prevalent	1052	141	39	1232	1131	87	14	1232	0.89	7
Thyagarajan	2006	PB	USA	Caucasian	PCR-RFLP	N/M	160	192	67	419	126	157	40	323	0.405	8
Vral	2011	HB	Italy	Caucasian	PCR-RFLP or SnapShot	N/M	13	22	9	44	54	84	30	168	0.964	2
Webb	2005	PB	Australia	Caucasian	Taq-Man	Prevalent	500	612	184	1296	248	321	91	660	0.425	8
Webb	2005	PB	Australia	Mixed	Taq-Man	Prevalent	91	44	14	149	59	54	15	128	0.625	8
Zhang	2005	HB	China	Asian	PCR-RFLP	Incident	33	80	107	220	29	115	166	310	0.17	3
BCAC HBBCS	2006	HB	Germany	Caucasian	Taq-Man & ARMS	N/M	95	119	42	1156	77	88	29	194	0.64	5
BCAC Madrid	2006	HB	Spain	Caucasian	Taq-Man & Illumina	N/M	255	274	92	621	281	287	105	673	0.028	6
BCAC SEARCH	2006	PB	UK	Caucasian	Taq-Man	N/M	1177	1462	465	3104	1607	1898	549	4054	0.76	9
BCAC Seoul	2006	HB	Korea	Asian	Taq-Man & SNPstream	N/M	502	53	1	556	355	31	0	386	0.411	8
BCAC Sheffield	2006	HB	UK	Caucasian	Taq-Man	N/M	458	555	168	1181	437	534	195	1166	0.144	7
BCAC USRTS	2006	PB	USA	Caucasian	Taq-Man	N/M	281	336	98	715	402	480	155	1037	0.55	7

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ISSN: 1471-2350

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