Associations between XRCC3 Thr241Met polymorphisms and breast cancer risk: systematic-review and meta-analysis of 55 case-control studies

Table 1 General characteristics of studies reporting associations in familial breast cancer (HB: hospital based, PB: population based, N/M: Not mentioned, HWE: Hardy-Weinberg Equilibrium, NOS: The Newcastle-Ottawa Scale, Quality of studies based on NOS star scoring system: 1–2 stars: poor, 3–5 stars: fair and 6–10 stars: good)

First Author	Year	Society	Country	Ethnicity	Genotyping Method	Case-enrollment strategy	Frequency in Cases				Frequency in Controls				HWE	NOS score
First Author	Year	Society	Country	Ethnicity	Genotyping Method	Case-enrollment strategy	TT	TM	MM	Total	TT	TM	MM	Total	HWE	NOS score
Costa	2007	HB	Portugal	Caucasian	PCR-RFLP	Prevalent	40	29	12	81	225	140	66	431	0	5
Dufloth	2005	HB	Brazil	Mixed	PCR-RFLP	Prevalent	27	18	7	52	68	35	15	118	0.005	3
Figueiredo	2004	PB	Canada	Caucasian	MALDI-TOF MS	Incident	29	38	16	83	13	20	4	37	0.341	9
Forsti	2004	PB	Finland	Caucasian	PCR-RFLP	Prevalent	72	85	15	172	89	88	25	202	0.654	4
Smith b	2003	HB	USA	Caucasian	PCR-RFLP	Incident	10	14	3	27	42	55	24	121	> 0.05	7
Vral	2011	HB	Italy	Caucasian	PCR-RFLP or SnapShot technique	N/M	60	87	23	170	54	84	30	168	0.964	2
Gonzalez-Hormazabal	2012	PB	Chile	Mixed	Taq-Man	Prevalent	187	103	32	322	335	209	23	567	0.177	7
Jara	2010	PB	Chile	Mixed	Conformation-sensitive gel electrophoresis (CSGE)	Prevalent	149	91	27	267	296	182	22	500	0.52	8

ISSN: 1471-2350