Weighted correlation network and differential expression analyses identify candidate genes associated with BRAF gene in melanoma

Zhao, Bin; You, Yanqiu; Wan, Zheng; Ma, Yunhan; Huo, Yani; Liu, Hongyi; Zhou, Yuanyuan; Quan, Wei; Chen, Weibin; Zhang, Xiaohong; Li, Fujun; Zhao, Yilin

doi:10.1186/s12881-019-0791-1

Table 2 The gene ontology analysis of potential key genes in melanomas

From: Weighted correlation network and differential expression analyses identify candidate genes associated with BRAF gene in melanoma

ID	Term	Count	p-value	Genes
GO:0016788	hydrolase activity, acting on ester bonds	2	0.00465	CYR61, RNASE4
GO:0090304	nucleic acid metabolic process	3	0.02260	CYR61, DUSP1, RNASE4
GO:0008219	cell death	2	0.03509	CYR61, DUSP1
GO:0071495	cellular response to endogenous stimulus	2	0.01713	CYR61, DUSP1
GO:0071310	cellular response to organic substance	2	0.04895	CYR61, DUSP1
GO:0009790	embryo development	2	0.008327	CYR61, DUSP1
GO:0048598	embryonic morphogenesis	2	0.00303	CYR61, DUSP1
GO:0019838	growth factor binding	2	0.00014	CYR61, DUSP1
GO:0006915	apoptotic process	2	0.03095	CYR61, DUSP1
GO:0043066	negative regulation of apoptotic process	2	0.00673	CYR61, DUSP1
GO:0060548	negative regulation of cell death	2	0.007915	CYR61, DUSP1
GO:0043069	negative regulation of programmed cell death	2	0.00688	CYR61, DUSP1
GO:0048646	anatomical structure formation involved in morphogenesis	2	0.01169	CYR61, DUSP1
GO:0016310	phosphorylation	2	0.04169	CYR61, DUSP1
GO:0043065	positive regulation of apoptotic process	2	0.00311	CYR61, DUSP1
GO:0010942	positive regulation of cell death	2	0.00354	CYR61, DUSP1
GO:0043068	positive regulation of programmed cell death	2	0.00316	CYR61, DUSP1
GO:0012501	programmed cell death	2	0.03166	CYR61, DUSP1
GO:0006468	protein phosphorylation	2	0.02993	CYR61, DUSP1
GO:0006508	proteolysis	2	0.02311	CYR61, DUSP1
GO:0070372	regulation of ERK1 and ERK2 cascade	2	0.00054	CYR61, DUSP1
GO:0043408	regulation of MAPK cascade	2	0.00578	CYR61, DUSP1
GO:0042981	regulation of apoptotic process	2	0.01902	CYR61, DUSP1
GO:0050790	regulation of catalytic activity	2	0.04813	CYR61, DUSP1
GO:0010941	regulation of cell death	2	0.02167	CYR61, DUSP1
GO:0051128	regulation of cellular component organization	2	0.04404	CYR61, DUSP1
GO:1902531	regulation of intracellular signal transduction	2	0.02427	CYR61, DUSP1
GO:0043549	regulation of kinase activity	2	0.00783	CYR61, DUSP1
GO:0019220	regulation of phosphate metabolic process	2	0.02663	CYR61, DUSP1
GO:0051174	regulation of phosphorus metabolic process	2	0.02702	CYR61, DUSP1
GO:0042325	regulation of phosphorylation	2	0.02016	CYR61, DUSP1
GO:0043067	regulation of programmed cell death	2	0.01933	CYR61, DUSP1
GO:0070371	ERK1 and ERK2 cascade	2	0.00060	CYR61, DUSP1
GO:0000165	MAPK cascade	2	0.00687	CYR61, DUSP1
GO:0009888	tissue development	2	0.02669	CYR61, DUSP1
GO:0044702	single organism reproductive process	2	0.01329	CYR61, DUSP1
GO:0023014	signal transduction by protein phosphorylation	2	0.00735	CYR61, DUSP1
GO:0009719	response to endogenous stimulus	2	0.02830	CYR61, DUSP1
GO:0022414	reproductive process	2	0.01641	CYR61, DUSP1
GO:0000003	reproduction	2	0.01646	CYR61, DUSP1
GO:0051338	regulation of transferase activity	2	0.01001	CYR61, DUSP1
GO:0030162	regulation of proteolysis	2	0.00476	CYR61, DUSP1
GO:0001932	regulation of protein phosphorylation	2	0.01783	CYR61, DUSP1
GO:0031399	regulation of protein modification process	2	0.02839	CYR61, DUSP1
GO:0045859	regulation of protein kinase activity	2	0.00701	CYR61, DUSP1

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ISSN: 1471-2350

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