Fig. 3

The number of previously reported MYO15A variants with a milder auditory phenotype in four periods (years 1998–2002, 2003–2007, 2008–2012 and 2013–2019). Several auditory phenotypes are considered as the milder auditory phenotype, such as mild /moderate /moderate-to-severe hearing loss, progressive post-lingual deafness and severe hearing loss with a typical slope toward high frequencies (residual hearing at low frequencies). The meaning of the numbers after the name of each country is the number of reported MYO15A variants with a milder auditory phenotype of each country in different periods. Following the rapid advance of molecular genetic techniques, there was an increasing number of reported MYO15A variants with milder auditory phenotypes in more countries worldwide, especially in Southeast Asia, such as China, Japan, and Korea. NA mean ethnic origin of patients were unavailable