Table 4 Multinomial logistic regression between the CHI3L1 SNP (rs946261) and the asthma clusters
| Â | Phenotype | N | rs946261 RAF | P value | Odds ratio (95% CI) | Sex (Female, %) | Age (range) | Never smoker (%) | Age of asthma onset (SD) | FEV1% predicted (SD) | Atop (%) | Log IgE (SD) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cluster A | Late-onset Mild Less-atopic | 203 | 0.68 | 0.027 | 1.29 (1.03–1.61) | 146 (72.3) | 67.6 (50–88) | 172 (84.6) | 59.5 (9.4) | 107.7 (12.8) | 88 (56.4) | 2.07 (0.62) |
Cluster B | Early-onset Mild | 200 | 0.63 | 0.88 | 0.98 (0.79–1.22) | 112 (56.3) | 35.4 (16–83) | 159 (79.5) | 10.3 (8.6) | 89.3 (13.8) | 162 (91.5) | 2.48 (0.71) |
Cluster C | Early-onset Moderate-to-severe | 94 | 0.68 | 0.20 | 1.23 (0.90–1.69) | 41 (44.1) | 42.8 (19–82) | 74 (78.7) | 14.9 (10.0) | 56.4 (11.6) | 76 (88.4) | 2.38 (0.59) |
Cluster D | Late-onset Severe | 91 | 0.66 | 0.41 | 1.14 (0.83–1.57) | 66 (73.3) | 65.2 (38–84) | 75 (82.4) | 48.6 (13.6) | 49.5 (9.9) | 47 (62.7) | 2.22 (0.65) |
Cluster E | Middle-age onset Female-dominant | 155 | 0.67 | 0.14 | 1.21 (0.94–1.55) | 127 (81.9) | 46.8 (21–81) | 111 (71.6) | 34.7 (8.1) | 104.3 (12.8) | 95 (69.9) | 2.04 (0.66) |
Cluster F | Late-onset Moderate Less atopic | 225 | 0.66 | 0.14 | 1.17 (0.95–1.44) | 167 (74.2) | 61.9 (31–88) | 183 (81.3) | 50.2 (12.1) | 77.6 (8.7) | 106 (57.9) | 2.19 (0.67) |