Association between KIF1B rs17401966 genetic polymorphism and hepatocellular carcinoma susceptibility: an updated meta-analysis

Table 3 Overall meta-analysis results with subgroup conducted by HBV status and ethnicity

Outcome/subgroup	Case	Control	Case vs Control			Heterogeneity		Egger’s test	Begg’s test
Outcome/subgroup	Case	Control	OR	95% CI	P	I²	P	P	P
G-allele vs A-allele
All	18,710	23,204	0.85	0.76–0.94	0.003	78.6%	< 0.001	0.307	0.649
HBV positive	12,584	13,852	0.82	0.72–0.95	0.007	81.9%	0.000
HBV negative	4270	7080	0.91	0.79–1.06	0.236	50.5%	0.109
Chinese	15,480	18,212	0.82	0.72–0.93	0.002	82.6%	< 0.001
Non-Chinese	1374	2720	0.99	0.84–1.15	0.855	0.0%	0.531
GG vs AA
All	4241	5301	0.72	0.52–0.99	0.044	77.7%	< 0.001	0.249	0.488
HBV positive	2377	2514	0.63	0.39–1.01	0.057	81.8%	0.000
HBV negative	1331	2131	0.91	0.65–1.29	0.603	50.0%	0.112
Chinese	3268	3775	0.64	0.43–0.95	0.028	82.9%	< 0.001
Non-Chinese	440	870	1.07	0.73–1.56	0.729	0.0%	0.538
AG vs AA
All	6185	8085	0.81	0.75–0.87	< 0.001	49.3%	0.016	0.686	0.843
HBV positive	3387	3802	0.76	0.66–0.89	0.001	54.9%	0.014
HBV negative	1949	3222	0.88	0.79–0.99	0.036	0.0%	0.644
Chinese	4705	5754	0.76	0.66–0.87	< 0.001	59.7%	0.006
Non-Chinese	631	1270	0.93	0.76–1.15	0.518	0.0%	0.868
GG vs AG
All	2886	4182	0.91	0.72–1.15	0.422	53.3%	0.008	0.253	0.692

ISSN: 1471-2350