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Fig. 3 | BMC Medical Genetics

Fig. 3

From: Vitamin D3 treatment differentially affects anxiety-like behavior in the old ovariectomized female rats and old ovariectomized female rats treated with low dose of 17β-estradiol

Fig. 3

Effects of Vitamin D3 administration on estradiol level of the old ovariectomized (OVX) rats following long-term estrogen deficiency in the serum blood. The obtained results show the mean ± standard error of the mean (SEM). *– p < 0.05 as compared to the control group of the old sham-operated rats; # – p < 0.05 as compared to the old OVX rats treated with solvent; $ – p < 0.05 as compared to the old OVX rats treated with 17β-estradiol (17β-E2). Each group comprised a minimum of eight rats. Cholecalciferol was given at 1.0, 2.5 or 5.0 mg/kg/day subcutaneously (s.c.), once daily, for 14 days. The administered dose of 17β-estradiol was 0.5 μg/rat s.c., once daily, for 14 days

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