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Fig. 2 | BMC Medical Genetics

Fig. 2

From: Vitamin D3 treatment differentially affects anxiety-like behavior in the old ovariectomized female rats and old ovariectomized female rats treated with low dose of 17β-estradiol

Fig. 2

Effects of Vitamin D3 administration on anxiety-like behavior of the old OVX rats following long-term estrogen deficiency in the light/dark test. a – time spent in the light box, sec; b – the number of entrances in the light box. The obtained results show the mean ± standard error of the mean (SEM). * – p < 0.05 as compared to the control group of sham-operated rats, # – p < 0.05 as compared to the old OVX rats treated with solvent, $ – p < 0.05 as compared to the old OVX rats treated with 17β-estradiol. Each group comprised a minimum of eight rats. Cholecalciferol was given at 1.0, 2.5 or 5.0 mg/kg/day s.c., once daily, for 14 days. The administered dose of 17β-estradiol (17β-E2) was 0.5 μg/rat s.c., once daily, for 14 days

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