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Table 6 Summary of meta-analysis on VDR gene variants and polycystic ovarian syndrome (PCOS) susceptibility

From: Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis

Polymoyphisms Population Genetic model Genetic model No. of studies Test of association Model Test of heterogeneity Egger’s test(P)
OR 95% CI P-value P-value I2 (%)
rs7975232 All C vs. A Allelic 9 1.19 1.06~1.34 0.004 F 0.170 32.5 0.676
VDR ApaI   CC vs. CA + AA Dominant 9 1.35 1.09~1.69 0.008 F 0.310 16.0 0.145
CC + CA vs. AA Recessive 9 1.20 1.01~1.42 0.042 F 0.050 50.0 0.132
Asian C vs. A Allelic 5 1.21 1.04~1.42 0.016 F 0.060 57.9 0.963
CC vs. CA + AA Dominant 5 1.70 1.26~2.29 0.001 F 0.700 0.0 0.265
CC + CA vs. AA Recessive 5 1.10 0.88~1.37 0.411 R 0.018 66.4 0.234
Caucasian C vs. A Allelic 4 1.17 0.98~1.38 0.053 F 0.849 0.0 0.452
CC vs. CA + AA Dominant 4 1.11 0.83~1.48 0.470 F 0.578 0.0 0.145
CC + CA vs. AA Recessive 4 1.32 0.89~1.46 0.084 F 0.683 0.0 0.247
rs1544410 All G vs. A Allelic 8 1.11 0.91~1.37 0.307 R 0.030 54.8 0.462
VDR BsmI   GG vs. GA + AA Dominant 8 0.94 0.75~1.17 0.556 F 0.280 20 0.563
GG + GA vs. AA Recessive 8 1.08 0.45~2.62 0.860 R 0.030 57 0.245
Asian G vs. A Allelic 5 1.27 1.06~1.53 0.011 F 0.114 46.3 0.256
GG vs. CA + AA Dominant 5 1.89 1.08~3.30 0.026 R 0.027 63.5 0.356
GG + GA vs. AA Recessive 5 1.54 0.63~3.76 0.342 R 0.001 86.1 0.235
Caucasian G vs. A Allelic 3 0.95 0.78~1.15 0.597 F 0.180 41.7 0.751
GG vs. CA + AA Dominant 3 0.57 0.27~1.18 0.128 R 0.002 84.3 0.156
GG + GA vs. AA Recessive 3 0.46 0.35~1.28 0.136 R 0.069 62.7 0.237
rs731236 All C vs. T Allelic 10 1.14 0.93~1.40 0.218 R 0.001 67.5 0.452
VDR TaqI   CC vs. TC + TT Dominant 10 1.20 0.84~1.71 0.322 R 0.006 61.1 0.564
CC + TC vs. TT Recessive 10 1.07 0.81~1.41 0.628 R 0.003 63.5 0.521
Asian C vs. T Allelic 6 1.09 0.85~1.41 0.493 R 0.034 58.6 0.426
CC vs. CT + TT Dominant 6 1.46 0.81~2.64 0.207 R 0.008 68.2 0.359
CC + CT vs. TT Recessive 6 1.02 0.83~1.24 0.858 F 0.128 41.6 0.215
Caucasian C vs. A Allelic 4 1.19 0.82~1.74 0.359 R 0.002 79.5 0.568
CC vs. CA + AA Dominant 4 1.01 0.63~1.63 0.961 R 0.062 59.1 0.356
CC + CA vs. AA Recessive 4 1.15 0.63~2.10 0.654 R 0.001 80.8 0.628
rs2228570 All T vs. C Allelic 7 1.04 0.83~1.30 0.715 R 0.050 52.3 0.539
VDR FokI   TT vs. CT + CC Dominant 7 0.90 0.65~1.24 0.521 F 0.291 18.1 0.759
TT + CT vs. CC Recessive 7 1.06 0.88~1.27 0.569 F 0.149 36.6 0.349
Asian T vs. C Allelic 5 1.13 0.94~1.37 0.190 F 0.150 40.8 0.564
TT vs. CT + CC Dominant 5 1.26 0.76~2.08 0.374 F 0.785 0.0 0.486
TT + CT vs. CC Recessive 5 1.15 0.92~1.44 0.233 F 0.136 42.8 0.843
Caucasian C vs. A Allelic 2 0.85 0.68~1.07 0.173 F 0.124 57.7
CC vs. CA + AA Dominant 2 0.65 0.29~1.44 0.284 R 0.084 66.5
CC + CA vs. AA Recessive 2 0.88 0.63~1.23 0.465 F 0.352 0.0
rs757343 All (Asian) A vs. G Allelic 3 1.04 0.81~1.34 0.734 F 0.939 0.0 0.428
VDR Tru9I   AA vs. AG + GG Dominant 3 1.09 0.52~2.28 0.830 F 0.753 0.0 0.740
AA+AG vs. GG Recessive 3 1.05 0.79~1.39 0.759 F 0.899 0.0 0.445
  1. F fixed effects model, R random effects model