Table 2 Meta-analysis of the pooled association between KIR polymorphisms and RA disease
Polymorphism | No. of studies | RA case n/N | Control n/N | P-value | Pooled OR (95% C.I) | Heterogeneity Test (Q, I2; P - value) | Publication Bias (Begg’s Test, P-value; Egger’s test, P-value) | Effect Model |
|---|---|---|---|---|---|---|---|---|
2DL1 | 8 | 1277/1371 | 1323/1395 | 0.736 | 0.865 (0.372–2.012) | (29.12, 73.8%; P-value < 0.001) | (Begg’s Test, 0.53; Egger’s test, 0.51) | Random |
2DL2 | 8 | 712/1371 | 748/1439 | 0.747 | 1.063 (0.735–1.536) | (35.34, 80.2%; P-value < 0.001) | (Begg’s Test, 0.38; Egger’s test, 0.28) | Random |
2DL3 | 9 | 1224/1411 | 1295/1435 | 0.047 | 0.591 (0.351–0.994) | (27.65, 71.1%; P-value < 0.001) | (Begg’s Test, 0.99; Egger’s test, 0.24) | Random |
2DL4 | 6 | 1075/1082 | 1059/1066 | 0.864 | 1.097 (0.382–3.152) | (0.15, 0.0%; P-value = 0.99) | (Begg’s Test, 0.09; Egger’s test, 0.001) | Fixed |
2DL5 | 7 | 614/1112 | 686/1096 | < 0.001 | 0.716 (0.601–0.853) | (8.3, 27.6%; P-value = 0.217) | (Begg’s Test, 0.99; Egger’s test, 0.59) | Fixed |
2DS1 | 8 | 623/1372 | 651/1389 | 0.560 | 0.932 (0.736–1.118) | (14.22, 50.7%; P-value = 0.047) | (Begg’s Test, 0.17; Egger’s test, 0.22) | Random |
2DS2 | 9 | 703/1441 | 734/1518 | 0.617 | 1.068 (0.826–1.380) | (19.98, 59.9%; P-value = 0.01) | (Begg’s Test, 0.35; Egger’s test, 0.25) | Random |
2DS3 | 8 | 372/1371 | 411/1395 | 0.176 | 0.891 (0.735–1.053) | (6.49, 0.0%; P-value = 0.483) | (Begg’s Test, 0.90; Egger’s test, 0.60) | Fixed |
2DS4 | 9 | 1153/1550 | 1094/1528 | 0.170 | 1.150 (0.942–1.404) | (12.57, 36.3%; P-value = 0.127) | (Begg’s Test, 0.25; Egger’s test, 0.28) | Fixed |
2DS5 | 8 | 386/1615 | 664/1989 | 0.045 | 0.623 (0.393–0.988) | (52.67, 86.7%; P-value < 0.001) | (Begg’s Test, 0.53; Egger’s test, 0.71) | Random |
3DL1 | 9 | 1296/1411 | 1338/1435 | 0.710 | 0.894 (0.494–1.616) | (25.07, 68.1%; P-value < 0.001) | (Begg’s Test, 0.25; Egger’s test, 0.067) | Random |
3DL2 | 7 | 1182/1204 | 1149/1160 | 0.157 | 0.585 (0.278–1.230) | (1.37, 0.0%; P-value = 0.967) | (Begg’s Test, 0.37; Egger’s test, 0.001) | Fixed |
3DL3 | 6 | 1067/1086 | 1060/1066 | 0.016 | 0.324 (0.129–0.814) | (4.28, 0.0%; P-value = 0.508) | (Begg’s Test, 0.19; Egger’s test, 0.001) | Fixed |
3DS1 | 8 | 511/1371 | 564/1395 | 0.569 | 0.917 (0.681–1.235) | (22.14, 68.4%; P-value = 0.002) | (Begg’s Test, 0.99; Egger’s test, 0.48) | Random |
2DP1 | 4 | 633/669 | 625/654 | 0.924 | 0.930 (0.206–4.185) | (14.1, 78.7%; P-value = 0.002) | (Begg’s Test, 0.73; Egger’s test, 0.85) | Random |
3DP1 | 3 | 603/606 | 575/578 | 0.976 | 1.025 (0.206–5.107) | (0.001, 0.0%; P-value = 0.99) | (Begg’s Test, NA; Egger’s test, NA) | Fixed |