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Table 2 HLOD Scores for Genome-wide Significant Chromosomal Regions

From: Exome genotyping and linkage analysis identifies two novel linked regions and replicates two others for myopia in Ashkenazi Jewish families

Chr cM Highest SNP (TP) or Gene (CHP) Max LOD Score Max HLOD Score Alpha for HLOD Max Multipoint HLOD near this location Alpha for Multipoint HLOD Max CHP HLOD at this location Alpha for CHP HLOD
1p36.12a 47.64 rs12748456b 4.47 4.47 1 1.21 0.15 3.49 0.48
8q24.22 147.50 rs72731540c 3.75 3.75 1 1.07 0.15 0.43 0.12
11p15.1d 30.74 NCR3LG1 1.27 2.78 0.55 0.27 0.05 3.66 0.57
7q36.1 161.66 SSPO 0.40 0.40 1 0.90 0.15 3.92 1
  1. a Multiple genome-wide significant two-point scores around this location. Also contained a single significant CHP variant, the LINC00339 gene
  2. b Intergenic variant located between LINC00339 and CDC42
  3. c Coding variant in WISP1
  4. d Multiple suggestive CHP scores in addition to the significant CHP score at this location
  5. This table describes the four chromosomal regions that contained at least one significant HLOD score in either the two-point or CHP linkage analyses. Column 1 shows the chromosomal region that was found to be significant and column 2 shows the position of the region in centimorgans. Column 3 reports the location of the highest HLOD score in the region. If the highest HLOD was in the two-point (TP) analysis, a SNP rsID is reported; if the highest HLOD occurred in the CHP analysis, a gene name is reported instead. Columns 4–6 report the maximum cumulative LOD score, HLOD score and associated alpha for the two-point analysis, columns 7–8 show the maximum multipoint HLOD closest to this location and its associated alpha, and columns 9–10 display the maximum CHP HLOD at this location and its associated alpha. The overall highest HLOD score for each region is shown in bold