TY - JOUR AU - Gilowska, Iwona AU - Majorczyk, Edyta AU - Kasper, Łukasz AU - Bogacz, Katarzyna AU - Szczegielniak, Jan AU - Kasper, Marta AU - Kaczmarski, Jacek AU - Skomudek, Aleksandra AU - Czerwinski, Marcin AU - Sładek, Krzysztof PY - 2019 DA - 2019/01/18 TI - The role of MMP-12 gene polymorphism − 82 A-to-G (rs2276109) in immunopathology of COPD in polish patients: a case control study JO - BMC Medical Genetics SP - 19 VL - 20 IS - 1 AB - Major symptoms of chronic obstructive pulmonary disease (COPD) are chronic bronchitis and emphysema leading from lung tissue destruction, that is an effect of an imbalance between metalloproteinases (MMPs) and their tissue inhibitors activity. As potential factor involved in this COPD pathogenesis, MMP-12 is considered. We investigated the role of genetic polymorphism and protein level of MMP-12 in the COPD development among Poles. SN - 1471-2350 UR - https://doi.org/10.1186/s12881-019-0751-9 DO - 10.1186/s12881-019-0751-9 ID - Gilowska2019 ER -