Glutathione S-transferase pi 1 variant and squamous cell carcinoma susceptibility: a meta-analysis of 52 case-control studies

Table 3 Subgroup analysis of the GSTP1 rs1695 A/G polymorphism by race, genotyping assay and control source

Factor	Subgroup	Index	Allele	Carrier	Homozygote	Heterozygote	Dominant	Recessive
Race	Asian	OR (95% CIs)	1.00 (0.89~1.12)	0.98 (0.86~1.11)	1.29 (0.94~1.76)	0.90 (0.78~1.04)	0.94 (0.82~1.08)	1.35 (0.99~1.83)
		P _a	0.948	0.716	0.114	0.139	0.361	0.058
		Case/control	1696/2139	1696/2139	1696/2139	1696/2139	1696/2139	1696/2139
		Study number	10	10	10	10	10	10
Race	Caucasian	OR (95% CIs)	0.98 (0.93~1.03)	0.98 (0.82~1.04)	1.00 (0.89~1.12)	0.94 (0.87~1.01)	0.95 (0.89~1.02)	1.02 (0.91~1.14)
		P _a	0.358	0.447	0.984	0.099	0.153	0.716
		Case/control	5968/9719	5968/9719	5968/9719	5968/9719	5968/9719	5968/9719
		Study number	30	30	30	30	30	30
genotyping assay	PCR-RFLP	OR (95% CIs)	0.99 (0.94~1.03)	0.99 (0.93~1.04)	1.01 (0.91~1.12)	0.96 (0.90~1.03)	0.97 (0.91~1.03)	1.01 (0.91~1.12)
		P _a	0.542	0.579	0.874	0.260	0.351	0.824
		Case/control	8008/11,342	8008/11,342	8008/11,342	8008/11,342	8008/11,342	8008/11,342
		Study number	42	42	42	42	42	42
control source	PB	OR (95% CIs)	0.98 (0.94~1.03)	0.98 (0.93~1.04)	1.00 (0.90~1.12)	0.96 (0.89~1.03)	0.96 (0.90~1.03)	1.02 (0.92~1.13)
		P _a	0.519	0.572	0.943	0.214	0.287	0.751
		Case/control	6697/10,170	6697/10,170	6697/10,170	6697/10,170	6697/10,170	6697/10,170
		Study number	31	31	31	31	31	31
control source	HB	OR (95% CIs)	0.98 (0.91~1.06)	0.98 (0.90~1.07)	1.00 (0.84~1.20)	0.95 (0.86~1.06)	0.96 (0.87~1.07)	1.01 (0.85~1.19)
		P _a	0.586	0.638	0.977	0.377	0.461	0.944
		Case/control	2771/3946	2771/3946	2771/3946	2771/3946	2771/3946	2771/3946
		Study number	19	19	19	19	19	19

P_a, P value of association test
PCR-RFLP polymerase chain reaction-restriction fragment length polymorphism, PB population-based, HB hospital-based, OR odds ratio, CIs confidence intervals

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