Table 2 APOBEC 3D, 3F, 3G and 3H nonsynonymous and synonymous changes, genotypes, amino acid position and change in the protein, frequencies and Hardy Weinberg Equilibrium calculations from the study population

 R6K (NI)

AGA➔AAA Transition

17G/G

17G/A

1

151 (89.9) 17 (10.1)

P-value = 0.49 X² = 0.48

 R97C (rs75858538)

CGC➔TGC Transition

289 C/C

289 C/T

289 T/T

1

148 (88.1) 19 (11.3) 1 (0.6)

P-value = 0.65 X² = 0.20

 L221R (NI)

CTG➔CGG Transition

662 T/T 662 T/G

5

165 (98.2) 3 (1.8)

P-value = 0.91 X² = 0.01

 C224Y (rs772893975)

TGT➔TAT Transition

671G/G 671G/A

5

161 (95.8) 7 (4.2)

P-value = 0.78 X² = 0.076

 T238A (rs201709403)

ACA➔GCA Transition

712A/A 712A/G

5

154 (91.7) 14 (8.3)

P-value = 0.57 X² = 0.32

 T238I (NI)

ACA➔ATA Transition

713C/C 713C/T

5

160(95.2) 8(4.8)

P-value = 0.75 X² = 0.10

 R248K (rs61748819)

AGG➔AAG Transition

743 G/G 743 G/A 743 A/A

5

133 (79.2) 33 (19.6) 2 (1.2)

P-value = 0.98 X² = 0.001

 C320Y (rs61999342)

TGC➔TAC Transition

959 G/G 959 G/A

6

167 (99.4) 1 (0.6)

P-value = 0.97 X² = 0.001

 L221 L (rs769426665)

CTG ➔CTC Transversion

663G/G 663G/C

5

165 (98.2) 3 (1.8)

P-value = 0.91 X² = 0.01

 T316 T (rs184448269)

ACC➔ACT Transition

948 C/C 948 C/T

6

161 (95.8) 7 (4.2)

P-value =0.78 X² = 0.08

 R48P (rs35053197) (in isoform 201 and 202)

CGT➔CCC Transversion

143 G/G 143 G/C

2

142 (92.2) 12 (7.8)

P-value = 0.61 X² = 0.25

 A78V (rs5750728) (only in isoform 201)

GCC➔GTC Transition

233 C/C 233 C/T 233 T/T

4

95 (61.7) 56 (36.4) 3 (1.9)

P-value = 0.10 X² = 2.64

 I87L (rs146543452) (only in isoform 201)

ATC➔CTC Transversion

259 A/A 259 A/C

4

153 (99.4) 1(0.6)

P-value = 0.97 X² = 0.002

 Q87L (rs114704208) (only in isoform 202)

CAG➔CTG Transversion

260 A/A 260 A/T

3

145 (94.2) 9 (6.8)

P-value = 0.71 X² = 0.14

 A108S (rs2020390) (only in isoform 201)

GCT➔TCT Transversion

322 G/G 322 G/T 322 T/T

4

54 (35.1) 84 (54.5) 16 (10.4)

P-value = 0.04 X² = 4.02

 V231I (rs2076101) (only in isoform 201)

GTC➔ATC Transition

691 G/G 691 G/A 691 A/A

5

122 (79.2) 30 (19.5) 2 (1.3)

P-value = 0.92 X² = 0.01

 Y307C (rs12157816) (only in isoform 201)

TAC➔TGC Transition

920 A/A 920 A/G

6

139 (90.3) 15 (9.7)

P-value = 0.52 X² = 0.40

 I117I (NI) (only in isoform 201)

ATC➔ATT Transition

351 C/C 351 C/T

4

152 (98.7) 2 (1.3)

P-value =0.94 X² = 0.007

 S118S (rs35928287) (only in isoform 201)

TCC➔TCT Transition

354 C/C 354 C/T

4

113 (73.4) 41 (26.6)

P-value =0.06 X² = 3.63

 R143R (rs4821862) (only in isoform 201)

CGC➔CGT Transition

429 C/C 429 C/T 429 T/T

4

19 (12.3) 91 (59.1) 44 (28.6)

P-value = 0.01 X² = 7.04

 Y196Y (rs765418322) (only in isoform 201)

TAT➔TAC Transition

588 T/T 588 T/C 588 C/C

4

126 (81.8) 24 (15.6) 4 (2.6)

P-value = 0.04 X² = 4.09

 S229S (rs549550231) (only in isoform 201)

TCA➔TCG Transition

687 A/A 687 A/G

5

152 (98.7) 2 (1.3)

P-value = 0.94 X² = 0.007

 E245E (rs113109079) (only in isoform 201)

GAG➔GAA Transition

735 G/G 735 G/A 735 A/A

5

146 (94.8) 7 (4.5) 1 (0.7)

P-value = 0.01 X² = 6.09

 S327S (rs35895636) (only in isoform 201)

TCC➔TCT Transition

981 C/C 981 C/T 981 T/T

5

128 (83.2) 23 (14.9) 3 (1.9)

P-value = 0.12 X² = 2.39

 H186R (rs8177832)

CAC➔CGC Transition

557 A/A5 557 A/G 557 G/G

4

63 (38.2) 82 (49.7) 20 (12.1)

P-value = 0.39 X² = 0.73

 R256H (rs17000736)

CGC➔CAC

Transition

767 G/G 767 G/A

6

161(97.6) 4 (2.4)

P-value = 0.87 X² = 0.02

 Q275E (rs17496046)

CAG➔GAG Transversion

823 C/C 823 C/G 823 G/G

6

111 (67.3) 49 (29.7) 5 (3.0)

P-value = 0.88 X² = 0.02

 G363R (rs148267053)

GGA➔AGA Transition

1087 G/G 1087 G/A

7

148 (89.7) 17 (10.3)

P-value = 0.49 X² = 0.49

 S60S (rs112603901)

TCC➔TCT Transition

180 C/C 180 C/T

3

147 (89.1) 18 (10.9)

P-value =0.46 X² = 0.55

 A109A (rs375760983)

GCC➔GCT Transition

327 C/C 327 C/T

3

164 (99.4) 1 (0.6)

P-value =0.97 X² = 0.002

 F119F (rs5757465)

TTT➔TTC Transition

357 T/T 357 T/C

3

164 (99.4) 1 (0.6)

P-value =0.97 X² = 0.002

 L371 L (rs11545130)

CTG➔TTG Transition

1111 C/C 1111 C/T

7

158 (95.8) 7 (4.2)

P-value =0.78 X² = 0.08

 N15Δ (rs140936762)

-CAA Deletion

45 CAA/CAA 45 CAA/ Δ 45 Δ / Δ

1

29 (21.8) 49 (36.8) 55 (41.4)

P-value = 0.001 X² = 10.25

 R18L (rs139293)

CGC➔CTC Transversion

53 G/G 53 G/T 53 T/T

1

112 (84.2) 15 (11.3) 6 (4.5)

P-value = 0.00 X² = 15.9

 G105R (rs139297)

GGC➔CGC Transversion

313 G/G 313 G/C 313 C/C

2

1 (0.8) 4 (3.0) 128 (96.2)

P-value = 0.00 X² = 13.4

 K121E (rs139298)

AAG➔GAG Transition

361 A/A 361 A/G 361 G/G

2

1 (0.8) 6 (4.5) 126 (94.7)

P-value = 0.01 X² = 6.9

 K140E (rs139300)

AAG➔GAG Transition

418 A/A 418 G/G

2

0133 (100)

P-value = N/A X² = N/A

 E178D (rs139302)

GAG➔GAC Transversion

534 G/G 534 G/C 534 C/C

3

3 (2.2) 11 (8.3) 119 (89.5)

P-value = 0.00 X² = 12.7

 T43 T (rs139294)

ACG➔ACC Transversion

129 G/G 129 G/C 129 C/C

1

6 (4.5) 7 (5.3) 120 (90.2)

P-value =0.00 X² = 48.4