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Table 2 Distributions of IL-17 SNPs genotypes in each group and analyses of associations between these polymorphisms and knee OA risk

From: Correlation between Interleukin-17 gene polymorphism and osteoarthritis susceptibility in Han Chinese population

Genotype Overall (N) Female (N) Male (N)
control OA OR (95% CI) P control OA OR (95% CI) P control OA OR (95% CI) P
Additive model
rs2275913 576 594    402 393    174 201   
GG 207 189 1.00 1.000 145 122 1.00 1.00 62 67 1.00 1.000
GA 265 271 1.12 (0.864–1.452) 0.427 184 179 1.156 (0.842–1.587) 0.376 81 92 1.051 (0.666–1.659) 0.907
AA 104 134 1.411 (1.021–1.950) 0.04 73 92 1.498 (1.014–2.213) 0.048 31 42 1.254 (0.703–2.236) 0.466
Allele
G 679 649 1.00 1.000 474 423 1.00 1.00 205 226 1.00 1.000
A 473 539 1.192 (1.012–1.404) 0.037 330 363 1.233 (1.011–1.503) 0.043 143 176 1.116 (0.835–1.493) 0.460
rs763780
TT 411 380 1.00 1.000 287 246 1.00 1.000 124 134 1.00 1.000
TC 155 188 1.312 (1.017–1.692) 0.039 108 131 1.415 (1.042–1.923) 0.029 47 57 1.122 (0.711–1.772) 0.643
CC 10 26 2.812 (1.338–5.909) 0.006 7 16 2.667 (1.079–6.588) 0.033 3 10 3.085 (0.830–11.468) 0.093
Allele
T 977 948 1.00 1.000 682 623 1.00 1.000 295 325 1.00 1.000
C 175 240 1.413 (1.141–1.751) 0.002 122 163 1.463 (1.129–1.894) 0.004 53 77 1.319 (0.899–1.935) 0.176
Dominant model
rs2275913
GG + GA 472 460 1.00 0.059 329 301 1.00 0.089 143 159 1.00 0.514
AA 104 134 1.322 (0.993–1.761)   73 92 1.378 (0.976–1.944)   31 42 1.219 (0.727–2.042)  
rs763780
TT + TC 566 568 1.00 0.01 395 377 1.00 0.058 171 191 1.00 0.098
CC 10 26 2.591 (1.238–5.422)   7 16 2.395 (0.974–5.886)   3 10 2.984 (0.808–11.023)  
Recessive model
rs2275913
GG 207 189 1.00 0.139 145 122 1.00 0.154 62 67 1.00 0.664
GA + AA 369 405 1.202 (0.943–1.532)   257 271 1.253 (0.933–1.684)   112 134 1.107 (0.722–1.697)  
rs763780
TT 411 380 1.00 0.007 287 246 1.00 0.01 124 134 1.00 0.372
TC + CC 165 214 1.403 (1.096–1.795)   115 147 1.491 (1.107–2.008)   50 67 1.240 (0.798–1.926)  
  1. OA osteoarthritis, OR odds ratio, CI confidence interval