Table 2 Distributions of IL-17 SNPs genotypes in each group and analyses of associations between these polymorphisms and knee OA risk
Genotype | Overall (N) | Female (N) | Male (N) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
control | OA | OR (95% CI) | P | control | OA | OR (95% CI) | P | control | OA | OR (95% CI) | P | |
Additive model | ||||||||||||
rs2275913 | 576 | 594 | Â | Â | 402 | 393 | Â | Â | 174 | 201 | Â | Â |
GG | 207 | 189 | 1.00 | 1.000 | 145 | 122 | 1.00 | 1.00 | 62 | 67 | 1.00 | 1.000 |
GA | 265 | 271 | 1.12 (0.864–1.452) | 0.427 | 184 | 179 | 1.156 (0.842–1.587) | 0.376 | 81 | 92 | 1.051 (0.666–1.659) | 0.907 |
AA | 104 | 134 | 1.411 (1.021–1.950) | 0.04 | 73 | 92 | 1.498 (1.014–2.213) | 0.048 | 31 | 42 | 1.254 (0.703–2.236) | 0.466 |
Allele | ||||||||||||
G | 679 | 649 | 1.00 | 1.000 | 474 | 423 | 1.00 | 1.00 | 205 | 226 | 1.00 | 1.000 |
A | 473 | 539 | 1.192 (1.012–1.404) | 0.037 | 330 | 363 | 1.233 (1.011–1.503) | 0.043 | 143 | 176 | 1.116 (0.835–1.493) | 0.460 |
rs763780 | ||||||||||||
TT | 411 | 380 | 1.00 | 1.000 | 287 | 246 | 1.00 | 1.000 | 124 | 134 | 1.00 | 1.000 |
TC | 155 | 188 | 1.312 (1.017–1.692) | 0.039 | 108 | 131 | 1.415 (1.042–1.923) | 0.029 | 47 | 57 | 1.122 (0.711–1.772) | 0.643 |
CC | 10 | 26 | 2.812 (1.338–5.909) | 0.006 | 7 | 16 | 2.667 (1.079–6.588) | 0.033 | 3 | 10 | 3.085 (0.830–11.468) | 0.093 |
Allele | ||||||||||||
T | 977 | 948 | 1.00 | 1.000 | 682 | 623 | 1.00 | 1.000 | 295 | 325 | 1.00 | 1.000 |
C | 175 | 240 | 1.413 (1.141–1.751) | 0.002 | 122 | 163 | 1.463 (1.129–1.894) | 0.004 | 53 | 77 | 1.319 (0.899–1.935) | 0.176 |
Dominant model | ||||||||||||
rs2275913 | ||||||||||||
GG + GA | 472 | 460 | 1.00 | 0.059 | 329 | 301 | 1.00 | 0.089 | 143 | 159 | 1.00 | 0.514 |
AA | 104 | 134 | 1.322 (0.993–1.761) |  | 73 | 92 | 1.378 (0.976–1.944) |  | 31 | 42 | 1.219 (0.727–2.042) |  |
rs763780 | ||||||||||||
TT + TC | 566 | 568 | 1.00 | 0.01 | 395 | 377 | 1.00 | 0.058 | 171 | 191 | 1.00 | 0.098 |
CC | 10 | 26 | 2.591 (1.238–5.422) |  | 7 | 16 | 2.395 (0.974–5.886) |  | 3 | 10 | 2.984 (0.808–11.023) |  |
Recessive model | ||||||||||||
rs2275913 | ||||||||||||
GG | 207 | 189 | 1.00 | 0.139 | 145 | 122 | 1.00 | 0.154 | 62 | 67 | 1.00 | 0.664 |
GA + AA | 369 | 405 | 1.202 (0.943–1.532) |  | 257 | 271 | 1.253 (0.933–1.684) |  | 112 | 134 | 1.107 (0.722–1.697) |  |
rs763780 | ||||||||||||
TT | 411 | 380 | 1.00 | 0.007 | 287 | 246 | 1.00 | 0.01 | 124 | 134 | 1.00 | 0.372 |
TC + CC | 165 | 214 | 1.403 (1.096–1.795) |  | 115 | 147 | 1.491 (1.107–2.008) |  | 50 | 67 | 1.240 (0.798–1.926) |  |