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Fig. 4 | BMC Medical Genetics

Fig. 4

From: Integrated molecular characterization of adult soft tissue sarcoma for therapeutic targets

Fig. 4

PDGFRA signaling pathway and drug sensitivity. a The sub-network that interacts with PDGFRA of the PDGF signaling pathway from REACTOME. Red or green nodes indicate up- or down-regulated genes in the PDGFRA-positive group compared with the CDK4 amplification group. Yellow border colors of nodes indicate significant differential gene expression between the PDGFRA-positive group and the CDK4 amplification group (P < 0.05; t-test). Edges between the nodes indicate the signaling interactions. Box plot of the average gene expression values (y-axis; PDGFRA sub-network, PDGFRA and CDK4, respectively) across samples within the sub-group (x-axis). P-values were calculated using the F-test. b Box plot of drug sensitivity (y-axis; -logIC50) in seven cell lines with CDK4 amplification (pink) and four cell lines with CDK4 normal copy number (green) across PDGFRA target drugs. P-values were calculated by the Wilcoxon rank-sum test. c Box plot of scores (y-axis) of pathways that enriched RB1 deletion across samples by sub-group (x-axis). P-values were calculated by the Kruskal-Wallis test

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