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Table 5 Correlations between measures of birth body composition and adult measures of insulin secretion

From: Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study

 

Birth weight (g)

Ponderal index

 

n

ρP

ρG (95% CI)

n

ρP

ρG (95% CI)

Insulin secretion in adulthood

HOMA-B (%)

376

- 0.01

- 0.22 (- 0.57; 0.13)

376

- 0.08

- 0.33 (- 0.76; 0.10)

BIGTT-AIR

349

0.11

- 0.03 (- 0.44; 0.38)

349

0.03

- 0.10 (- 0.61; 0.41)

Insulinogenic index

348

0.06

0.08 (- 0.31; 0.47)

348

- 0.02

- 0.18 (- 0.67; 0.31)

AUC insulin 4 h (pmol/l*min)

345

- 0.14*

- 0.29 (- 0.72; 0.14)

345

- 0.14*

- 0.66 (- 1.13; - 0.19)*#

Fasting serum insulin (pmol/l)

377

- 0.09

- 0.28 (- 0.61; 0.05)

377

- 0.13*

- 0.47 (- 0.86;− 0.08)*#

  1. Phenotypic correlations between traits were estimated as ρP, and genetic correlations were estimated as ρG (95% CI). Correlations were estimated in non-diabetic relatives of patients with type 2 diabetes mellitus. All correlations were adjusted for sex. *Correlation significantly different from zero (p < 0.05). #Correlation remained significant following adjustment for both birth weight and adult type 2 diabetes susceptibility SNPs
  2. AUC: area under the curve, BIGTT-AIR: index for acute insulin response, HOMA-B: HOMA for beta cell function