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Table 5 Correlations between measures of birth body composition and adult measures of insulin secretion

From: Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study

  Birth weight (g) Ponderal index
  n ρP ρG (95% CI) n ρP ρG (95% CI)
Insulin secretion in adulthood
HOMA-B (%) 376 - 0.01 - 0.22 (- 0.57; 0.13) 376 - 0.08 - 0.33 (- 0.76; 0.10)
BIGTT-AIR 349 0.11 - 0.03 (- 0.44; 0.38) 349 0.03 - 0.10 (- 0.61; 0.41)
Insulinogenic index 348 0.06 0.08 (- 0.31; 0.47) 348 - 0.02 - 0.18 (- 0.67; 0.31)
AUC insulin 4 h (pmol/l*min) 345 - 0.14* - 0.29 (- 0.72; 0.14) 345 - 0.14* - 0.66 (- 1.13; - 0.19)*#
Fasting serum insulin (pmol/l) 377 - 0.09 - 0.28 (- 0.61; 0.05) 377 - 0.13* - 0.47 (- 0.86;− 0.08)*#
  1. Phenotypic correlations between traits were estimated as ρP, and genetic correlations were estimated as ρG (95% CI). Correlations were estimated in non-diabetic relatives of patients with type 2 diabetes mellitus. All correlations were adjusted for sex. *Correlation significantly different from zero (p < 0.05). #Correlation remained significant following adjustment for both birth weight and adult type 2 diabetes susceptibility SNPs
  2. AUC: area under the curve, BIGTT-AIR: index for acute insulin response, HOMA-B: HOMA for beta cell function