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Table 4 Correlations between measures of birth body composition and adult measures of insulin sensitivity

From: Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study

 

Birth weight (g)

Ponderal index

 

n

ρP

ρG (95% CI)

n

ρP

ρG (95% CI)

Insulin sensitivity in adulthood

HOMA-IR

376

- 0.12

- 0.31 (- 0.64; 0.02)

376

- 0.09

- 0.35 (- 0,76; 0.06)

Matsuda insulin sensitivity index

376

0.15*

0.36 (0.03; 0.69)*#

376

0.14*

0.52 (0.15; 0.89)*#

  1. Phenotypic correlations between traits were estimated as ρP, and genetic correlations were estimated as ρG (95% CI). Correlations were estimated in non-diabetic relatives of patients with type 2 diabetes mellitus. All correlations were adjusted for sex. *Correlation significantly different from zero (p < 0.05). #Correlation remained significant following adjustment for both birth weight and adult type 2 diabetes susceptibility SNPs. All genetic correlations were significantly different from 1 (p < 0.05)