Skip to main content

Advertisement

Table 3 Heritability estimates

From: Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study

Body composition measured at birth
 Trait n h2 (95% CI) c2 (95% CI) e2 (95% CI)
 Birth weight (g) 297 0.80 (0.37; 1.23)* 0.05 (−0.20; 0.30) 0.15 (−0.09; 0.39)
 Ponderal index 296 0.46 (0.01; 0.91)* 0.02 (− 0.18; 0.22) 0.53 (0.22; 0.84)*
 Birth length (cm) 296 0.15 (−0.54; 0.84) 0.17 (−0.18; 0.52) 0.67 (0.30; 1.04)*
Adult body composition
 Weight (kg) 406 0.35 (0.04; 0.66)* 0.01 (−0.15; 0.17) 0.64 (0.42; 0.86)*
 Height (cm) 406 0.30 (0.01; 0.59)* 0.32 (0.12; 0.52)* 0.39 (0.21; 0.57)*
 Waist (cm) 398 0.28 (−0.01; 0.57)* 0.03 (−0.13; 0.19) 0.69 (0.49; 0.89)*
 Waist-hip ratio 397 0.34 (0.14; 0.54)* 0 (0) 0.66 (0.46; 0.86)*
 BMI (kg/m2) 406 0.32 (0.03; 0.61)* 0.07 (−0.07; 0.21) 0.61 (0.39; 0.83)*
 Fat mass (kg) 338 0.50 (0.26; 0.74)* 0 (0) 0.50 (0.26; 0.74)*
 Fat free mass (kg) 338 0.09 (−0.52; 0.70) 0.17 (−0.16; 0.50) 0.74 (0.39; 1.09)*
Adult measures of glycaemic control
 Insulin secretion
 HOMA-B (%) 367 0.27 (−0.06; 0.60)* 0.02 (−0.16; 0.20) 0.71 (0.38; 1.04)*
 BIGTT-AIR 312 0.31 (0.09; 0.53)* 0 (0) 0.69 (0.47; 0.91)*
 Insulinogenic index 318 0.25 (0.03; 0.47)* 0 (0) 0.75 (0.53; 0.97)*
 AUC insulin 4 h (pmol/l*min) 302 0.25 (1.01; 0.49)* 0 (0) 0.75 (0.51; 0.99)*
Insulin sensitivity
 HOMA-IR 367 0.37 (0.12; 0.62)* 0 (0) 0.63 (0.38; 0.88)*
 Matsuda insulin sensitivity index 367 0.31 (0.07; 0.55)* 0 (0) 0.69 (0.45; 0.93)*
  1. Heritabillity estimates were calculated using the ACE model. All heritability estimates were adjusted for sex, and heritability estimates of adult measures were additionally adjusted for age
  2. BIGTT-AIR: index for acute insulin response, c2 = common environmental effect, e2 = unique environmental effect, h2 = additive genetic effect. *Heritability estimate significantly different from zero (p < 0.05)