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Table 3 Heritability estimates

From: Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study

Body composition measured at birth

 Trait

n

h2 (95% CI)

c2 (95% CI)

e2 (95% CI)

 Birth weight (g)

297

0.80 (0.37; 1.23)*

0.05 (−0.20; 0.30)

0.15 (−0.09; 0.39)

 Ponderal index

296

0.46 (0.01; 0.91)*

0.02 (− 0.18; 0.22)

0.53 (0.22; 0.84)*

 Birth length (cm)

296

0.15 (−0.54; 0.84)

0.17 (−0.18; 0.52)

0.67 (0.30; 1.04)*

Adult body composition

 Weight (kg)

406

0.35 (0.04; 0.66)*

0.01 (−0.15; 0.17)

0.64 (0.42; 0.86)*

 Height (cm)

406

0.30 (0.01; 0.59)*

0.32 (0.12; 0.52)*

0.39 (0.21; 0.57)*

 Waist (cm)

398

0.28 (−0.01; 0.57)*

0.03 (−0.13; 0.19)

0.69 (0.49; 0.89)*

 Waist-hip ratio

397

0.34 (0.14; 0.54)*

0 (0)

0.66 (0.46; 0.86)*

 BMI (kg/m2)

406

0.32 (0.03; 0.61)*

0.07 (−0.07; 0.21)

0.61 (0.39; 0.83)*

 Fat mass (kg)

338

0.50 (0.26; 0.74)*

0 (0)

0.50 (0.26; 0.74)*

 Fat free mass (kg)

338

0.09 (−0.52; 0.70)

0.17 (−0.16; 0.50)

0.74 (0.39; 1.09)*

Adult measures of glycaemic control

 Insulin secretion

 HOMA-B (%)

367

0.27 (−0.06; 0.60)*

0.02 (−0.16; 0.20)

0.71 (0.38; 1.04)*

 BIGTT-AIR

312

0.31 (0.09; 0.53)*

0 (0)

0.69 (0.47; 0.91)*

 Insulinogenic index

318

0.25 (0.03; 0.47)*

0 (0)

0.75 (0.53; 0.97)*

 AUC insulin 4 h (pmol/l*min)

302

0.25 (1.01; 0.49)*

0 (0)

0.75 (0.51; 0.99)*

Insulin sensitivity

 HOMA-IR

367

0.37 (0.12; 0.62)*

0 (0)

0.63 (0.38; 0.88)*

 Matsuda insulin sensitivity index

367

0.31 (0.07; 0.55)*

0 (0)

0.69 (0.45; 0.93)*

  1. Heritabillity estimates were calculated using the ACE model. All heritability estimates were adjusted for sex, and heritability estimates of adult measures were additionally adjusted for age
  2. BIGTT-AIR: index for acute insulin response, c2 = common environmental effect, e2 = unique environmental effect, h2 = additive genetic effect. *Heritability estimate significantly different from zero (p < 0.05)