Relationship between transforming growth factor-β1 and type 2 diabetic nephropathy risk in Chinese population

Zhou, Tianbiao; Li, Hong-Yan; Zhong, Hongzhen; Zhong, Zhiqing

doi:10.1186/s12881-018-0717-3

BMC Medical Genetics

Table 1 General characteristics of the included studies for TGF-β1 levels in T2DN in this meta-analysis

From: Relationship between transforming growth factor-β1 and type 2 diabetic nephropathy risk in Chinese population

First author, year	Country	According to	Case			Control
First author, year	Country	UAER or UACR	Mean	SD	N	Mean	SD	N
Ju HB 2000	China	Normoalbuminuria	35.02	6.7	14	23.95	8.01	15
		Microalbuminuria	39.31	5.35	18	23.95	8.01	15
		Macroalbuminuria	58.58	9.56	13	23.95	8.01	15
Wang YJ 2002	China	Normoalbuminuria	147.03	22.57	34	136.97	37.96	35
Wang YJ 2002	China	Macroalbuminuria	170.65	18.74	31	136.97	37.96	35
Li WM 2004	China	Normoalbuminuria	58.91	11.03	46	47.25	6.22	48
Li WM 2004	China	Macroalbuminuria	387.45	82.06	48	47.25	6.22	48
Li ZJ 2004	China	Normoalbuminuria	146	22	36	131	36	40
Li ZJ 2004	China	Macroalbuminuria	172	19	44	131	36	40
Jiang ZL 2005	China	Normoalbuminuria	428.3	43.7	29	412.5	58.4	35
		Microalbuminuria	578.5	69.4	27	412.5	58.4	35
		Macroalbuminuria	683.4	84.3	28	412.5	58.4	35
Li ZZ 2005	China	Normoalbuminuria	41	15.57	27	10.04	5.33	18
		Microalbuminuria	66.35	18.04	12	10.04	5.33	18
		Macroalbuminuria	53.31	15.64	18	10.04	5.33	18
Zhou Y 2005	China	Normoalbuminuria	31.12	12.39	30	29.4	10.62	30
		Microalbuminuria	79.63	15.96	30	29.4	10.62	30
		Macroalbuminuria	136.6	21.45	30	29.4	10.62	30
Jing CY 2005	China	Normoalbuminuria	31.16	14.23	31	24.58	12.61	20
		Microalbuminuria	48.2	18.3	25	24.58	12.61	20
		Macroalbuminuria	62.12	21.3	23	24.58	12.61	20
Wei YS 2005	China	NR	41.57	10.55	91	25.46	7.88	105
Li HP 2006	China	Normoalbuminuria	147.02	20.57	108	131.96	3.84	120
Li HP 2006	China	Macroalbuminuria	170.64	17.72	132	131.96	3.84	120
Tao SP 2006	China	Normoalbuminuria	147	23	28	132	36	25
Tao SP 2006	China	Macroalbuminuria	172	18	34	132	36	25
Meng T 2006	China	Normoalbuminuria	217.7	126	28	84.5	23.4	30
		Microalbuminuria	288.2	109.4	24	84.5	23.4	30
		Macroalbuminuria	345.5	118.2	22	84.5	23.4	30
Xie HF 2006	China	Normoalbuminuria	42.1	9.3	60	35.9	8.1	30
Xie HF 2006	China	Macroalbuminuria	61.8	11.2	45	35.9	8.1	30
Qian YX 2006	China	Normoalbuminuria	146	22	48	131	36	60
Qian YX 2006	China	Macroalbuminuria	172	19	23	131	36	60
Fu CX 2007	China	Normoalbuminuria	36.2	8.8	34	34.4	8.2	35
Fu CX 2007	China	Microalbuminuria	69.4	12.8	31	34.4	8.2	35
Du JW 2007	China	Normoalbuminuria	179.16	13.13	20	68.47	31.75	19
		Microalbuminuria	192.66	57.25	21	68.47	31.75	19
		Macroalbuminuria	582.04	211.25	20	68.47	31.75	19
Zhang WJ 2007	China	Normoalbuminuria	23.35	3.7	36	20.35	3.7	40
		Microalbuminuria	41.31	4.3	45	20.35	3.7	40
		Macroalbuminuria	55.28	6.8	45	20.35	3.7	40
Lai X 2007	China	Normoalbuminuria	89.65	28.33	27	31.46	9.07	43
		Microalbuminuria	121.02	32.36	21	31.46	9.07	43
		Macroalbuminuria	211.69	69.83	17	31.46	9.07	43
Lin YH 2007	China	Normoalbuminuria	97.24	18.6	19	58.36	13.72	23
Lin YH 2007	China	Macroalbuminuria	136.75	23.48	24	58.36	13.72	23
Zhang SF 2007	China	Microalbuminuria	21.188	20.87	15	6.99	18.57	18
Zhang SF 2007	China	Macroalbuminuria	13.64	19.44	16	6.99	18.57	18
Zhang WK 2008	China	Normoalbuminuria	23.3	10.1	30	20.3	3.7	26
		Microalbuminuria	41.3	4.2	38	20.3	3.7	26
		Macroalbuminuria	88.2	6.8	32	20.3	3.7	26
Wang YP 2008	China	Normoalbuminuria	35.4	7.1	44	32.5	6.8	35
Wang YP 2008	China	Macroalbuminuria	68.2	12.5	32	32.5	6.8	35
Zhang SB 2008	China	NR	121.5	37.2	36	55.2	16.8	30
Li QX 2008	China	Normoalbuminuria	31.9	9.72	26	21.5	6.89	20
		Microalbuminuria	49.6	14.78	23	21.5	6.89	20
		Macroalbuminuria	70.3	26.48	18	21.5	6.89	20
Feng SJ 2008	China	Normoalbuminuria	208.2	110	25	80.62	3.4	38
		Microalbuminuria	293.3	118.5	23	80.62	3.4	38
		Macroalbuminuria	263.5	108.2	18	80.62	3.4	38
Zhang HM 2008	China	Normoalbuminuria	32.52	12.24	40
Zhang HM 2008	China	Microalbuminuria	43.61	20.37	48
Cao B 2009	China	Normoalbuminuria	31.2	5.6	31	17.4	3.4	30
		Microalbuminuria	54.9	7.8	34	17.4	3.4	30
		Macroalbuminuria	78.2	10.3	30	17.4	3.4	30
Li QX 2009	China	Normoalbuminuria	31.9	9.72	26	21.5	6.89	20
		Microalbuminuria	49.6	14.78	23	21.5	6.89	20
		Macroalbuminuria	70.3	26.48	18	21.5	6.89	20
Yang YZ 2010	China	Normoalbuminuria	28.59	3.64	25	21.07	3.48	30
Yang YZ 2010	China	Macroalbuminuria	43.12	4.62	25	21.07	3.48	30
Feng LM 2010	China	Normoalbuminuria	34.2	7.1	40	32.8	6.4	35
Feng LM 2010	China	Macroalbuminuria	69.4	7.2	32	32.8	6.4	35
Wu YJ 2010	China	NG	172.5	20.4	30	125.4	14.6	28
Ye CF 2010	China	Normoalbuminuria	31.36	5.75	37	26.54	5.78	32
Ye CF 2010	China	Macroalbuminuria	58.69	9.87	37	26.54	5.78	32
Huang JW 2010	China	Normoalbuminuria	41.85	10.38	29	22.5	5.75	30
		Microalbuminuria	79.51	44.95	32	22.5	5.75	30
		Macroalbuminuria	118.15	59.38	28	22.5	5.75	30
Chen D 2011	China	Normoalbuminuria	129.16	27.08	30	83.32	30.55	60
		Microalbuminuria	162.97	98.58	30	83.32	30.55	60
		Macroalbuminuria	563.46	122.67	30	83.32	30.55	60
Li QX 2011	China	Normoalbuminuria	31.9	9.72	26	21.5	6.89	20
		Microalbuminuria	49.6	14.78	23	21.5	6.89	20
		Macroalbuminuria	70.3	26.48	18	21.5	6.89	20
Zhou ZX 2011	China	Normoalbuminuria	33.12	8.16	50	32.98	7.83	50
Zhou ZX 2011	China	Microalbuminuria	49.21	18.11	56	32.98	7.83	50
He Y 2012	China	Normoalbuminuria	147.01	20.98	48	131.82	36.01	60
He Y 2012	China	Macroalbuminuria	172.31	19.06	42	131.82	36.01	60
Zhang Y 2012	China	NG	154.8	7.09	28	122.84	6.3	15
Du ZC 2013	China	Normoalbuminuria	18.55	2.67	20	8.97	4.087	18
		Microalbuminuria	19.04	2.87	20	8.97	4.087	18
		Macroalbuminuria	18.12	3.17	21	8.97	4.087	18
Zhang WQ 2014	China	Normoalbuminuria	30.3	4.42	32	24.52	2.81	23
		Microalbuminuria	34.32	4.32	41	24.52	2.81	23
		Macroalbuminuria	58.31	5.16	13	24.52	2.81	23
Liu S 2014	China	Normoalbuminuria	76.8	3.1	30	29.6	2.5	30
		Microalbuminuria	114.8	3.1	30	29.6	2.5	30
		Macroalbuminuria	135.8	5.9	30	29.6	2.5	30
Bao HL 2014	China	Microalbuminuria	75.4	9.2	33	71.2	11.1	36
Feng R 2015	China	Normoalbuminuria	7.58	2.11	22	5.13	1.63	30
		Microalbuminuria	11.89	3.33	29	5.13	1.63	30
		Macroalbuminuria	24.62	6.62	35	5.13	1.63	30
Lv C 2015	China	Normoalbuminuria	27.3	5.45	137	14.98	3.23	131
		Microalbuminuria	51.8	5.72	122	14.98	3.23	131
		Macroalbuminuria	72.97	6.05	68	14.98	3.23	131
Bi FC 2016	China	Normoalbuminuria	5.61	2.08	21	1.79	1.64	20
		Microalbuminuria	8.98	2.26	20	1.79	1.64	20
		Macroalbuminuria	11.39	1.61	20	1.79	1.64	20

NR: not report

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