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Table 2 Results of meta-analysis for polymorphisms in and cancer susceptibility

From: Do polymorphisms in protein kinase catalytic subunit alpha-1 gene associated with cancer susceptibility? a meta-analysis and systematic review

Comparison

Subgroup

N

P H

P Z

P Adjust

Random (OR, 95%CI)

Fixed (OR, 95%CI)

rs10074991

 B VS. A

overall

3

0.006

6.752*10−3

3.376*10–2*

0.774 (0.642–0.931)

0.795 (0.735–0.861)

 B VS. A

Asian

2

0.908

2.169*10−10

1.085*10–9*

0.704 (0.632–0.785)

0.704 (0.632–0.785)

 BB vs. AA

overall

3

0.002

2.787*10−2

0.139

0.610 (0.393–0.946)

0.627 (0.528–0.745)

 BB vs. AA

Asian

2

0.954

1.972*10−10

9.86*10–10*

0.489 (0.392–0.609)

0.489 (0.392–0.609)

 BA vs. AA

overall

3

0.163

3.895*10−5

1.948*10–4*

0.755 (0.633–0.900)

0.779 (0.691–0.877)

 BA vs. AA

Asian

2

0.903

4.946*10−5

2.473*10–4*

0.675 (0.558–0.816)

0.675 (0.558–0.816)

 BB + BA vs. AA

overall

3

0.011

8.421*10−3

4.211*10–2*

0.697 (0.533–0.912)

0.752 (0.672–0.842)

 BB + BA vs. AA

Asian

2

0.900

5.381*10−8

2.691*10–7*

0.607 (0.507–0.727)

0.607 (0.507–0.727)

 BB vs. BA+AA

overall

3

0.029

3.610*10−2

0.181

0.737 (0.554–0.980)

0.729 (0.628–0.846)

 BB vs. BA+AA

Asian

2

0.999

7.752*10−7

3.876*10–6*

0.638 (0.534–0.762)

0.638 (0.534–0.762)

rs13361707

 B VS. A

overall

19

6.416*10−72

0.159

0.795

0.900 (0.776–1.042)

0.931 (0.904–0.959)

 B VS. A

Asian

18

1.644*10−72

0.188

0.940

0.904 (0.777–1.051)

0.932 (0.905–0.960)

 B VS. A

GC

16

2.061*10−72

0.121

0.605

0.873 (0.736–1.037)

0.917 (0.889–0.947)

 B VS. A

ESCC

2

0.749

0.884

1.000

1.006 (0.927–1.092)

1.006 (0.927–1.092)

 B VS. A

PB

16

6.359*10−73

0.299

1.000

0.920 (0.786–1.077)

0.933 (0.906–0.961)

 B VS. A

HB

3

0.167

0.061

0.305

0.773 (0.555–1.076)

0.793 (0.622–1.010)

 BB vs. AA

overall

19

6.471*10−71

0.166

0.830

0.810 (0.601–1.092)

0.868 (0.819–0.921)

 BB vs. AA

Asian

18

1.516*10−71

0.191

0.955

0.816 (0.602–1.106)

0.869 (0.819–0.922)

 BB vs. AA

GC

16

2.211*10− 71

0.127

0.635

0.763 (0.539–1.080)

1.013 (0.859–1.196)

 BB vs. AA

ESCC

2

0.765

0.875

1.000

0.844 (0.792–0.899)

1.013 (0.859–1.196)

 BB vs. AA

PB

16

4.978*10−72

0.300

1.000

0.845 (0.615–1.161)

0.872 (0.822–0.925)

 BB vs. AA

HB

3

0.182

0.088

0.440

0.592 (0.286–1.224)

0.630 (0.371–1.071)

 BA vs. AA

overall

19

2.232*10−20

0.192

0.960

0.900 (0.768–1.054)

0.946 (0.899–0.996)

 BA vs. AA

Asian

18

8.982*10− 21

0.224

1.000

0.904 (0.768–1.064)

0.948 (0.900–0.998)

 BA vs. AA

GC

16

1.397*10−21

0.184

0.920

0.883 (0.734–1.061)

0.937 (0.886–0.990)

 BA vs. AA

ESCC

2

0.727

0.912

1.000

1.008 (0.871–1.167)

1.008 (0.871–1.167)

 BA vs. AA

PB

16

9.406*10−21

0.320

1.000

0.919 (0.778–1.086)

0.950 (0.902–1.001)

 BA vs. AA

HB

3

0.121

0.155

0.775

0.730 (0.417–1.277)

0.768 (0.534–1.105)

 BB + BA vs. AA

overall

19

1.835*10−44

0.168

0.840

0.869 (0.711–1.061)

0.916 (0.873–0.962)

 BB + BA vs. AA

Asian

18

5.451*10−45

0.195

0.975

0.873 (0.71–1.072)

0.918 (0.874–0.963)

 BB + BA vs. AA

GC

16

1.594*10−45

0.145

0.725

0.841 (0.666–1.062)

0.901 (0.856–0.949)

 BB + BA vs. AA

ESCC

2

0.707

0.892

1.000

1.010 (0.879–1.159)

1.010 (0.879–1.159)

 BB + BA vs. AA

PB

16

5.135*10−45

0.309

1.000

0.895 (0.723–1.108)

0.920 (0.876–0.966)

 BB + BA vs. AA

HB

3

0.085

0.208

1.000

0.692 (0.389–1.228)

0.737 (0.522–1.041)

 BB vs. BA+AA

overall

19

2.761*10−46

0.193

0.965

0.874 (0.714–1.071)

0.902 (0.860–0.946)

 BB vs. BA+AA

Asian

18

7.547*10−47

0.217

1.000

0.878 (0.715–1.079)

0.902 (0.860–0.947)

 BB vs. BA+AA

GC

16

1.034*10−46

0.135

0.675

0.836 (0.660–1.058)

0.882 (0.838–0.929)

 BB vs. BA+AA

ESCC

2

0.892

0.917

1.000

1.007 (0.883–1.148)

1.007 (0.883–1.148)

 BB vs. BA+AA

PB

16

7.502*10−48

0.293

1.000

0.891 (0.719–1.105)

0.904 (0.861–0.948)

 BB vs. BA+AA

HB

3

0.681

0.219

1.000

0.747 (0.470–1.188)

0.746 (0.470–1.184)

  1. PH P value of Q test for heterogeneity test, PZ means statistically significant, PAdjust Multiple testing P value according to Bonferroni Correction, H-B Hospital based, P-B Population based, HWE Hardy Weinberg Equilibrium; Note: Heterogeneity was considered to be significant when the P-value was less than 0.1. If there was no significant heterogeneity, a fixed effect model (Der-Simonian Laird) was used to evaluate the point estimates and 95% CI; otherwise, a random effects model (Der-Simonian Laird) was used. And the Pz was calculated based on the actual model adopted. "*" indicated that PAdjust value less than 0.05, and is considered as statistically significant  
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BMC Medical Genetics

ISSN: 1471-2350

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