Table 3 Putative Ancestry-Specific Variants Conferring Risk of PPROM

Present in cases only in WES?

Yes^a

Yes^a

Yes

Validated by Sanger sequencing?

Yes^a

Yes^a

Yes

Rare?

Yes

Yes

Yes

African ancestry?

Yes

Yes

Yes

Under selective pressure?

Yes

Yes

?

Heterozygous impact?

Plausible

Plausible

?

Expressed in fetal membranes?

Yes

Yes^a

Yes

Plausible pathophysiology?

Yes

Yes

?

Replication?

Yes

Yes

No