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Fig. 6 | BMC Medical Genetics

Fig. 6

From: A novel mutation in the CRYAA gene associated with congenital cataract and microphthalmia in a Chinese family

Fig. 6

Localization of wild-type and R12L mutated αA-crystallin proteins. Photomicrographs show the distribution of immunoreactive αA-crystallin (green) and DAPI-stained nuclei (blue) in HeLa cells. Both wild-type CRYAA and mutated R12L-CRYAA proteins were predominantly localized in the cytoplasm. Cells transfected with wild-type CRYAA showed a homogenous distribution of the protein in the cytoplasm and there was little or no aggregation in the cells. In contrast, the cells transfected with the mutant R12L-CRYAA showed significant intracellular aggregation in a number of cells

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BMC Medical Genetics

ISSN: 1471-2350

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