GDF5 rs143383 | Subgroup | Assessment of association | Assessment of heterogeneity | ||||
---|---|---|---|---|---|---|---|
OR | 95% CI | P | Pooling model | I2 (%) | P | ||
Allelic model | Overall | 1.32 | 1.19–1.48 | 0.000 | Random | 72.8 | 0.000 |
Disease | |||||||
IDD | 1.45 | 1.13–1.86 | 0.004 | Random | 67.6 | 0.005 | |
OA | 1.28 | 1.14–1.44 | 0.000 | Random | 73.4 | 0.000 | |
Ethnicity | |||||||
Asian | 1.49 | 1.25–1.77 | 0.000 | Random | 83.2 | 0.000 | |
Caucasian | 1.18 | 1.09–1.28 | 0.000 | Fixed | 17.1 | 0.276 | |
Homozygote model | Overall | 1.80 | 1.49–2.16 | 0.000 | Fixed | 47.5 | 0.007 |
Disease | |||||||
IDD | 2.33 | 1.55–3.51 | 0.000 | Fixed | 29.5 | 0.203 | |
OA | 1.67 | 1.36–2.05 | 0.000 | Random | 50.1 | 0.014 | |
Ethnicity | |||||||
Asian | 2.28 | 1.71–3.05 | 0.000 | Random | 58.9 | 0.009 | |
Caucasian | 1.46 | 1.23–1.74 | 0.000 | Fixed | 0.0 | 0.460 | |
Heterozygote model | Overall | 1.37 | 1.21–1.55 | 0.000 | Fixed | 26.7 | 0.122 |
Disease | |||||||
IDD | 1.84 | 1.34–2.52 | 0.000 | Fixed | 0.0 | 0.926 | |
OA | 1.29 | 1.13–1.48 | 0.000 | Fixed | 38.4 | 0.065 | |
Ethnicity | |||||||
Asian | 1.49 | 1.25–1.78 | 0.000 | Fixed | 15.5 | 0.300 | |
Caucasian | 1.27 | 1.07–1.51 | 0.006 | Fixed | 33.8 | 0.120 | |
Dominant model | Overall | 1.56 | 1.39–1.75 | 0.000 | Fixed | 40.5 | 0.026 |
Disease | |||||||
IDD | 2.11 | 1.57–2.86 | 0.000 | Fixed | 0.0 | 0.569 | |
OA | 1.46 | 1.29–1.66 | 0.000 | Fixed | 46.2 | 0.026 | |
Ethnicity | |||||||
Asian | 1.82 | 1.54–2.16 | 0.000 | Fixed | 47.8 | 0.045 | |
Caucasian | 1.35 | 1.15–1.58 | 0.000 | Fixed | 14.9 | 0.299 | |
Recessive model | Overall | 1.39 | 1.20–1.60 | 0.000 | Random | 73.3 | 0.000 |
Disease | |||||||
IDD | 1.44 | 1.02–2.04 | 0.037 | Random | 71.4 | 0.002 | |
OA | 1.35 | 1.16–1.59 | 0.000 | Random | 74.0 | 0.000 | |
Ethnicity | |||||||
Asian | 1.55 | 1.25–1.92 | 0.000 | Random | 83.2 | 0.000 | |
Caucasian | 1.21 | 1.03–1.42 | 0.019 | Fixed | 36.2 | 0.101 |