Association between GDF5 rs143383 genetic polymorphism and musculoskeletal degenerative diseases susceptibility: a meta-analysis

Huang, Xin; Zhang, Weiyue; Shao, Zengwu

doi:10.1186/s12881-018-0685-7

Table 1 Main characteristics of the studies included in this meta-analysis

From: Association between GDF5 rs143383 genetic polymorphism and musculoskeletal degenerative diseases susceptibility: a meta-analysis

First author	Year	Country	Ethnicity	Sample size		Disease	Sex	Age (y)	Genotyping method	Quality	Citation
First author	Year	Country	Ethnicity	Case	Control	Disease	Sex	Age (y)	Genotyping method	Quality	Citation
Mu J	2014	China	Asian	231	370	LDH	Both	21.9	DNA analyzers	Y	[17]
Mu J	2013	China	Asian	305	587	LBP	Both	48.4	DNA analyzers	Y	[18]
Williams FMK ^a	2011	UK	Caucasian	194	1268	LDD	Both	65.7	KASPar chemistry	Y	[19]
Williams FMK ^b	2011	UK	Caucasian	33	539	LDD	Both	54.7	KASPar chemistry	Y	[19]
Williams FMK ^c	2011	UK	Caucasian	54	704	LDD	Both	62.9	KASPar chemistry	Y	[19]
Williams FMK ^d	2011	UK	Caucasian	18	574	LDD	Both	53.6	KASPar chemistry	Y	[19]
Williams FMK ^e	2011	UK	Caucasian	14	116	LDD	Both	65.8	KASPar chemistry	Y	[19]
Tülüce Y	2017	Turkey	Caucasian	95	77	OA	Both	62.5	PCR-RFLP	Y	[20]
Abd Elazeem MI	2017	Egypt	Caucasian	50	50	Primary knee OA	Both	56.5	TaqMan	Y	[21]
Sabah-Ozcan S	2016	Turkey	Caucasian	94	279	Knee OA	Both	58.4	PCR-RFLP	Y	[22]
Xiao JL	2015	China	Asian	114	126	Temporomandibular joint OA	Both	33.6	PCR-RFLP	Y	[23]
Mishra A	2013	India	Asian	300	300	Knee OA	Both	54.0	PCR-RFLP	Y	[5]
Tawonsawatruk T	2011	Thailand	Asian	90	103	Knee OA	Both	68.5	PCR-RFLP	Y	[29]
Cao Z	2010	Korea	Asian	276	298	Knee OA	Both	63.0	PCR-RFLP	Y	[30]
Valdes AM	2009	UK	Caucasian	259	509	Knee OA	Both	68.5	Allele-specific PCR	Y	[31]
Tsezou A	2007	Greece	Caucasian	251	268	Knee OA	Both	67.9	Direct sequence	Y	[32]
Miyamoto Y ^a	2007	Japan	Asian	718	861	Knee OA	Both	71.9	TaqMan	Y	[33]
Miyamoto Y ^b	2007	China	Asian	313	485	Knee OA	Both	58.8	TaqMan	Y	[33]
Miyamoto Y ^c	2007	Japan	Asian	998	983	Hip OA	Both	71.9	TaqMan	Y	[33]
Southam L ^a	2007	UK	Caucasian	509	822	Knee OA	Both	65.0	PCR-RFLP	Y	[34]
Southam L ^b	2007	Spain	Caucasian	274	1196	Knee OA	Both	65.0	TaqMan	Y	[34]
Shin MH	2012	Korea	Asian	725	1737	Knee OA	Both	67.4	High resolution melting analysis	Y	[35]

^a,b,c,dand ^e denote an independent study in one article, respectively; LDD lumbar disc degeneration, LDH lumbar disc herniation, LBP low-back pain, OA osteoarthritis, RT-PCR real-time polymerase chain reaction, PCR-RFLP polymerase chain reaction-restriction fragment-length polymorphism, Y yes

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