The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women

Mondockova, Vladimira; Adamkovicova, Maria; Lukacova, Martina; Grosskopf, Birgit; Babosova, Ramona; Galbavy, Drahomir; Martiniakova, Monika; Omelka, Radoslav

doi:10.1186/s12881-018-0684-8

Table 7 BMD changes after raloxifene therapy in relation to the rs9340799 and rs2234693 genotypes

From: The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women

Genotype	Skeletal site	BMD before treatment	BMD after treatment	BMD difference after treatment	GLM Sig. (P value)	PC Sig. (P value)
GG	FN T-score	−2.222 ± 0.160	−1.744 ± 0.201	0.478 ± 0.105	0.002
GG	FN BMD	0.591 ± 0.019	0.649 ± 0.024	0.057 ± 0.013 (+ 10.2%)	0.002
AG	FN T-score	−2.196 ± 0.100	−1.717 ± 0.126	0.478 ± 0.157	0.006
AG	FN BMD	0.595 ± 0.012	0.652 ± 0.015	0.057 ± 0.019 (+ 9.9%)	0.006
AA	FN T-score	−2.119 ± 0.086	−2.113 ± 0.108	0.006 ± 0.058	NS
AA	FN BMD	0.604 ± 0.010	0.604 ± 0.013	0.001 ± 0.007 (+ 0.46%)	NS
GG-AG	FN T-score				NS for FN T-score and FN BMD
GG-AG	FN BMD
GG-AA	FN T-score
GG-AA	FN BMD
AG-AA	FN T-score
AG-AA	FN BMD
GG	LS T-score	−2.856 ± 0.145	−2.244 ± 0.167	0.611 ± 0.082	0.001
GG	LS BMD	0.677 ± 0.016	0.743 ± 0.018	0.065 ± 0.009 (+ 9.7%)	0.001
AG	LS T-score	−2.935 ± 0.091	−2.226 ± 0.105	0.709 ± 0.087	0.001
AG	LS BMD	0.669 ± 0.010	0.745 ± 0.011	0.076 ± 0.009 (+ 11.5%)	0.001
AA	LS T-score	−2.994 ± 0.078	−2.765 ± 0.090	0.229 ± 0.094	0.021
AA	LS BMD	0.663 ± 0.008	0.687 ± 0.010	0.025 ± 0.010 (+ 4.1%)	0.021
GG-AG	LS T-score			0.030 ± 0.161	0.016 for FN T-score and FN BMD	NS
GG-AG	LS BMD			0.003 ± 0.017		NS
GG-AA	LS T-score			0.329 ± 0.155		NS
GG-AA	LS BMD			0.035 ± 0.017		NS
AG-AA	LS T-score			0.299 ± 0.113		0.028
AG-AA	LS BMD			0.032 ± 0.012		0.028
CC	FN T-score	−2.227 ± 0.145	−1.855 ± 0.177	0.373 ± 0.093	0.002
CC	FN BMD	0.591 ± 0.017	0.635 ± 0.021	0.045 ± 0.092 (+ 7.8%)	0.002
TC	FN T-score	−2.132 ± 0.086	−1.719 ± 0.106	0.413 ± 0.124	0.002
TC	FN BMD	0.602 ± 0.010	0.652 ± 0.013	0.050 ± 0.015 (+ 8.6%)	0.002
TT	FN T-score	−2.171 ± 0.105	−2.238 ± 0.128	0.067 ± 0.060	NS
TT	FN BMD	0.597 ± 0.013	0.589 ± 0.015	−0.008 ± 0.007 (−1.0%)	NS
CC-TC	FN T-score				NS for FN T-score and FN BMD
CC-TC	FN BMD
CC-TT	FN T-score
CC-TT	FN BMD
TC-TT	FN T-score
TC-TT	FN BMD
CC	LS T-score	−2.809 ± 0.130	−2.264 ± 0.140	0.546 ± 0.092	0.001	0.001
CC	LS BMD	0.682 ± 0.014	0.741 ± 0.015	0.058 ± 0.010 (+ 8.6%)	0.001	0.001
TC	LS T-score	−2.942 ± 0.077	−2.265 ± 0.084	0.677 ± 0.074	0.001	0.001
TC	LS BMD	0.668 ± 0.008	0.741 ± 0.009	0.073 ± 0.008 (+ 11.0%)	0.001	0.001
TT	LS T-score	−3.043 ± 0.094	−2.952 ± 0.102	0.091 ± 0.114	NS	NS
TT	LS BMD	0.657 ± 0.010	0.667 ± 0.011	0.010 ± 0.012 (+ 2.0%)	NS	NS
CC-TC	LS T-score			0.067 ± 0.137	0.001 for FN T-score and FN BMD	NS
CC-TC	LS BMD			0.007 ± 0.015		NS
CC-TT	LS T-score			0.461 ± 0.145		0.007
CC-TT	LS BMD			0.049 ± 0.016		0.007
TC-TT	LS T-score			0.394 ± 0.110		0.002
TC-TT	LS BMD			0.042 ± 0.012		0.002

BMD of femoral neck (FN) and lumbal spine (LS) is expressed as Estimated Marginal Mean ± SE (SE – standard error of the mean) of T-score (FN and LS T-score) and g/cm² (FN and LS BMD); GLM Sig. – significance of GLM, PC Sig. – significance of pairwise comparisons, NS – non-significant GLM/BMD differences, P values determine significant BMD differences (P < 0.05)

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