The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women

Table 4 The effects of the rs9340799 and rs2234693 genotypes on fracture prevalence

Fracture location	Genotypes	Presence of fractures	Absence of fractures	P value	OR	95% CI
rs9340799:A > G genotypes
Spinal	GG	12	40	0.744	0.869	0.373–2.024
	AG	43	114	0.464	0.764	0.437–1.458
	AA	36	98
Radial	GG	8	44	0.501	0.722	0.279–1.868
	AG	27	130	0.371	0.735	0.375–1.442
	AA	21	113
Total	GG	13	39	0.913	1.046	0.469–2.330
	AG	48	109	0.632	0.871	0.495–1.533
	AA	42	92
rs2234693:T > C genotypes
Spinal	CC	17	56	0.861	0.930	0.414–2.092
	TC	48	127	0.759	0.903	0.472–1.729
	TT	26	69
Radial	CC	10	63	0.856	0.918	0.363–2.322
	TC	31	144	0.501	0.779	0.377–1.610
	TT	15	80
Total	CC	18	55	0.858	1.073	0.497–2.315
	TC	56	119	0.583	0.843	0.458–1.552
	TT	29	66

The total number values count a presence of any fracture in an individual, OR - the odds ratio, CI - confidence interval, AA and TT genotypes were set as baseline categories in a regression model; femoral fractures were not evaluated

ISSN: 1471-2350