Fig. 2

Renal pathological findings of 2 patients with multicentric carpotarsal osteolysis syndrome. In Patient 1, light microscopy (a) shows a glomerulus with segmental sclerosis (arrow), tubular atrophy, and interstitial fibrosis (hematoxylin and eosin, × 200). Electron microscopy (b) reveals wide effacement of foot process (arrow). (scale bar = 10 μm) In Patient 2, light microscopy shows a glomerulus perihilar segmental sclerosis (c, periodic acid–Schiff, × 400) and mild to moderate tubulointerstitial fibrosis with tubular atrophy (d, Masson’s trichrome, × 200), and electron microscopy (e) reveals wide effacement of the foot processes with occasional villous transformation and hydropic change of podocytes. (scale bar = 10 μm)