Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis

Table 5 Association between IL1B haplotype combinations and risk of ankylosing spondylitis (AS). The haplotype combinations in IL1B described 97% of the genotypes observed

Haplotype combinations	Haplotypes			N_AS (%)	N_Control (%)	OR^a	(95% CI)	P-value
Haplotype combinations	rs4848306 -3737G > A [69, 70]	rs1143623 -1464G > C [69, 71]	rs1143627 -31 T > C [69, 71, 72]	N_AS (%)	N_Control (%)	OR^a	(95% CI)	P-value
11	A:A	G:G	T:T	125 (18)	148 (20)	1.00	–	–
22	G:G	C:C	C:C	52 (8)	54 (7)	1.14	0.73–1.79	0.65
33	G:G	G:G	T:T	32 (5)	41 (5)	0.92	0.55–1.55	0.79
44	G:G	G:G	C:C	5 (1)	3 (0)	1.97	0.46–8.42	0.48
12	A:G	G:C	T:C	163 (24)	185 (24)	1.04	0.76–1.43	0.81
13	A:G	G:G	T:T	141 (20)	147 (19)	1.14	0.82–1.58	0.50
14	A:G	G:G	T:C	44 (6)	38 (5)	1.37	0.84–2.25	0.26
23	G:G	C:G	C:T	84 (12)	92 (12)	1.08	0.74–1.58	0.70
24	G:G	C:G	C:C	28 (4)	34 (4)	0.98	0.56–1.70	1.00
34	G:G	G:G	T:C	14 (2)	16 (2)	1.04	0.49–2.21	1.00

OR Odds ratio
The variant allele of −3737 G > A [69], −1464 G > C [70] and − 31 T > C [71, 72] have been shown to decrease IL-1β level [69,70,71,72]
^aOR was calculated for each haplotype combination by using the haplotype 11 as reference group

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