Table 4 Association between TLR4 haplotype combinations and risk of ankylosing spondylitis (AS). The haplotype combinations in TLR4 described 94% of the genotypes observed
Haplotype combinations | Haplotypes | NAS (%) | NControl (%) | ORa | (95% CI) | P-value | ||
|---|---|---|---|---|---|---|---|---|
rs12377632 T > C | rs1554973 T > C | rs5030728 G > A | ||||||
11 | C:C | T:T | G:G | 95 (14) | 101 (14) | 1.00 | – | – |
22 | T:T | T:T | A:A | 69 (10) | 74 (10) | 0.99 | 0.64–1.53 | 1.00 |
33 | T:T | C:C | G:G | 29 (4) | 57 (8) | 0.54 | 0.32–0.92 | 0.03 |
44 | T:T | T:T | G:G | 3 (0) | 5 (1) | 0.64 | 0.15–2.74 | 0.72 |
12 | T:C | T:T | G:A | 154 (23) | 188 (25) | 0.87 | 0.61–1.24 | 0.47 |
13 | T:C | T:C | G:G | 126 (19) | 129 (17) | 1.04 | 0.72–1.51 | 0.85 |
14 | T:C | T:T | G:G | 30 (5) | 32 (4) | 1.00 | 0.56–1.77 | 1.00 |
23 | T:T | T:C | G:A | 99 (15) | 106 (14) | 0.99 | 0.67–1.47 | 1.00 |
24 | T:T | T:T | G:A | 31 (5) | 24 (3) | 1.37 | 0.75–2.51 | 0.36 |
34 | T:T | T:C | G:G | 28 (4) | 26 (4) | 1.14 | 0.63–2.09 | 0.76 |