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Table 3 Association of the TLR2 haplotype combinations and risk of ankylosing spondylitis (AS). The haplotype combinations in TLR2 described 93% of the genotypes observed

From: Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis

Haplotype combinations

Haplotypes

NAS (%)

NControl (%)

ORa

(95% CI)

P-value

rs4696480 A > T

rs11938228 C > A

rs3804099 T>Cb

11

T:T

A:A

T:T

69 (11)

76 (10)

1.00

–

–

22

A:A

C:C

C:C

72 (11)

74 (10)

1.07

0.68–1.70

0.82

33

A:A

C:C

T:T

28 (4)

34 (5)

0.91

0.50–1.65

0.76

44

T:T

C:C

C:C

14 (2)

10 (1)

1.52

0.64–3.70

0.38

12

T:A

C:A

C:T

158 (24)

197 (27)

0.88

0.60–1.30

0.55

13

T:A

C:A

T:T

76 (12)

103 (14)

0.81

0.52–1.26

0.37

14

T:T

C:A

C:T

59 (9)

49 (7)

1.33

0.80–2.19

0.31

23

A:A

C:C

C:T

77 (12)

89 (12)

0.95

0.61–1.49

0.91

24

T:A

C:C

C:C

52 (8)

55 (8)

1.04

0.63–1.72

0.90

34

T:A

C:C

C:T

51 (8)

44 (6)

1.28

0.76–2.14

0.43

  1. OR Odds ratio
  2. aOR was calculated for each haplotype combination by using the haplotype 11 as reference group
  3. bThe variant allele of rs3804099T T > C has been shown to decrease TNF-α, IL-1β & IL-6 level [68]